Title |
An Overview of the Modulatory Effects of Oleic Acid in Health and Disease
|
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Published in |
Mini Reviews in Medicinal Chemistry, January 2013
|
DOI | 10.2174/1389557511313020003 |
Pubmed ID | |
Authors |
Helioswilton Sales-Campos, Patricia Reis de Souza, Bethanea Crema Peghini, Joao Santana da Silva, Cristina Ribeiro Cardoso |
Abstract |
Evidences in the last years have showed the effects of oleic acid (OA) in human health and disease. Olive oil, rich in oleic acid, is supposed to present modulatory effects in a wide physiological functions, while some studies also suggest a beneficial effect on cancer, autoimmune and inflammatory diseases, besides its ability to facilitate wound healing. Although the OA role in immune responses are still controversial, the administration of olive oil containing diets may improve the immune response associated to a more successful elimination of pathogens such as bacteria and fungi, by interfering in many components of this system such as macrophages, lymphocytes and neutrophils. Then, novel putative therapies for inflammatory and infectious diseases could be developed based on the characteristics presented by unsaturated fatty acids like OA. Finally, the purpose of this work was to review some of the modulatory effects of OA on inflammatory diseases and health, aiming at high lightening its potential role on the future establishment of novel therapeutic approaches for infections, inflammatory, immune, cardiovascular diseases or skin repair based on this fatty acid mainly found in the Mediterranean diet. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 443 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 69 | 16% |
Student > Ph. D. Student | 53 | 12% |
Student > Master | 52 | 12% |
Researcher | 46 | 10% |
Student > Doctoral Student | 34 | 8% |
Other | 66 | 15% |
Unknown | 123 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 100 | 23% |
Biochemistry, Genetics and Molecular Biology | 46 | 10% |
Medicine and Dentistry | 33 | 7% |
Chemistry | 26 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 18 | 4% |
Other | 75 | 17% |
Unknown | 145 | 33% |