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C-reactive protein levels in stable COPD patients: a case-control study

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, August 2015
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Citations

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29 Mendeley
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Title
C-reactive protein levels in stable COPD patients: a case-control study
Published in
International Journal of Chronic Obstructive Pulmonary Disease, August 2015
DOI 10.2147/copd.s87015
Pubmed ID
Authors

Denise Rossato Silva, Marli Knorst, Marcelo Gazzana

Abstract

Previous studies have documented that C-reactive protein (CRP) levels are increased in stable COPD patients. However, most studies have also shown that higher CRP levels are observed in patients with comorbidities like diabetes mellitus and cardiovascular disease. We aimed to investigate if CRP levels are increased in stable COPD patients, and if there is an association between CRP levels and pulmonary function tests and clinical characteristics. We conducted a case-control study in a tertiary care, university-affiliated hospital. COPD patients and controls were matched for sex and age in a 2:1 matching ratio. We included only those patients who had quit smoking. CRP levels were determined and pulmonary function tests were performed in both the groups. A total of 60 COPD patients and 30 controls were included in the analysis. The study subjects had a mean age of 64.8±8.5 years in COPD group and 64.3±9.2 years in control group (P=0.214). The median of CRP levels was 3.17 mg/L (interquartile range [IQR]: 1.73-5.99 mg/L) in COPD group and 2.13 mg/L (IQR: 1.18-7.69 mg/L) in control group (P=0.370). There were 34 (56.7%) patients in COPD group and 14 (46.7%) patients in control group with CRP levels greater than 3 mg/dL (P=0.382). Using bivariate correlations, we found significant positive correlations in COPD patients between body mass index (BMI) and CRP (r=0.3, P=0.045), and between CRP and forced vital capacity (FVC, % of predicted) (r=-0.3; P=0.023). In a multivariate model, female sex and FVC (% of predicted) were associated with a CRP value greater than 3 mg/dL in the COPD group. The levels of CRP in the stable COPD patients were not significantly different when compared to those in the control subjects. Female sex and FVC (% predicted) were associated with CRP levels greater than 3 mg/dL in the COPD group.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 5 17%
Student > Bachelor 4 14%
Student > Master 3 10%
Researcher 2 7%
Professor > Associate Professor 2 7%
Other 4 14%
Unknown 9 31%
Readers by discipline Count As %
Medicine and Dentistry 10 34%
Nursing and Health Professions 2 7%
Computer Science 2 7%
Social Sciences 2 7%
Economics, Econometrics and Finance 1 3%
Other 1 3%
Unknown 11 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2015.
All research outputs
#10,685,112
of 14,054,251 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,257
of 1,733 outputs
Outputs of similar age
#149,944
of 239,627 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#69
of 90 outputs
Altmetric has tracked 14,054,251 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,733 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,627 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.