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C-reactive protein levels in stable COPD patients: a case-control study

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, August 2015
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Title
C-reactive protein levels in stable COPD patients: a case-control study
Published in
International Journal of Chronic Obstructive Pulmonary Disease, August 2015
DOI 10.2147/copd.s87015
Pubmed ID
Authors

Denise Rossato Silva, Marcelo Basso Gazzana, Marli Maria Knorst

Abstract

Previous studies have documented that C-reactive protein (CRP) levels are increased in stable COPD patients. However, most studies have also shown that higher CRP levels are observed in patients with comorbidities like diabetes mellitus and cardiovascular disease. We aimed to investigate if CRP levels are increased in stable COPD patients, and if there is an association between CRP levels and pulmonary function tests and clinical characteristics. We conducted a case-control study in a tertiary care, university-affiliated hospital. COPD patients and controls were matched for sex and age in a 2:1 matching ratio. We included only those patients who had quit smoking. CRP levels were determined and pulmonary function tests were performed in both the groups. A total of 60 COPD patients and 30 controls were included in the analysis. The study subjects had a mean age of 64.8±8.5 years in COPD group and 64.3±9.2 years in control group (P=0.214). The median of CRP levels was 3.17 mg/L (interquartile range [IQR]: 1.73-5.99 mg/L) in COPD group and 2.13 mg/L (IQR: 1.18-7.69 mg/L) in control group (P=0.370). There were 34 (56.7%) patients in COPD group and 14 (46.7%) patients in control group with CRP levels greater than 3 mg/dL (P=0.382). Using bivariate correlations, we found significant positive correlations in COPD patients between body mass index (BMI) and CRP (r=0.3, P=0.045), and between CRP and forced vital capacity (FVC, % of predicted) (r=-0.3; P=0.023). In a multivariate model, female sex and FVC (% of predicted) were associated with a CRP value greater than 3 mg/dL in the COPD group. The levels of CRP in the stable COPD patients were not significantly different when compared to those in the control subjects. Female sex and FVC (% predicted) were associated with CRP levels greater than 3 mg/dL in the COPD group.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 15%
Student > Bachelor 6 15%
Student > Postgraduate 5 12%
Unspecified 2 5%
Researcher 2 5%
Other 7 17%
Unknown 13 32%
Readers by discipline Count As %
Medicine and Dentistry 13 32%
Nursing and Health Professions 4 10%
Unspecified 2 5%
Computer Science 2 5%
Social Sciences 2 5%
Other 2 5%
Unknown 16 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2015.
All research outputs
#19,942,460
of 25,382,035 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,932
of 2,569 outputs
Outputs of similar age
#187,505
of 274,817 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#64
of 87 outputs
Altmetric has tracked 25,382,035 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,569 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,817 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.