Title |
Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery
|
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Published in |
International Journal of Nanomedicine, September 2015
|
DOI | 10.2147/ijn.s88381 |
Pubmed ID | |
Authors |
Jae Yeon Joo, Gil Yong Park, Seong Soo A An |
Abstract |
In the development of effective drug delivery carriers, many researchers have focused on the usage of nontoxic and biocompatible materials and surface modification with targeting molecules for tumor-specific drug delivery. Fibrinogen (Fbg), an abundant glycoprotein in plasma, could be a potential candidate for developing drug carriers because of its biocompatibility and tumor-targeting property via arginine-glycine-aspartate (RGD) peptide sequences. Doxorubicin (DOX), a chemotherapeutic agent, was covalently conjugated to Fbg, and the microspheres were prepared. Acid-labile and non-cleavable linkers were used for the conjugation of DOX to Fbg, resulting in an acid-triggered drug release under a mild acidic condition and a slow-controlled drug release, respectively. In vitro cytotoxicity tests confirmed low cytotoxicity in normal cells and high antitumor effect toward cancer cells. In addition, it was discovered that a longer linker could make the binding of cells to Fbg drug carriers easier. Therefore, DOX-linker-Fbg microspheres could be a suitable drug carrier for safer and effective drug delivery. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 6% |
Unknown | 15 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 3 | 19% |
Student > Doctoral Student | 2 | 13% |
Researcher | 2 | 13% |
Professor > Associate Professor | 2 | 13% |
Student > Master | 2 | 13% |
Other | 4 | 25% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 4 | 25% |
Agricultural and Biological Sciences | 3 | 19% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Environmental Science | 1 | 6% |
Other | 4 | 25% |
Unknown | 1 | 6% |