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25-Hydroxyvitamin D insufficiency discriminates cardiovascular risk factors accumulation in peri-pubertal boys undergoing overweight screening

Overview of attention for article published in Endocrine, September 2015
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Title
25-Hydroxyvitamin D insufficiency discriminates cardiovascular risk factors accumulation in peri-pubertal boys undergoing overweight screening
Published in
Endocrine, September 2015
DOI 10.1007/s12020-015-0725-4
Pubmed ID
Authors

Andrea Di Nisio, Luca De Toni, Elvio D’Addato, Maria R. Pizzo, Pasquale Sabatino, Carlo Foresta

Abstract

The aim of this study was to evaluate the possible association between cardiometabolic risk factors accumulation and vitamin D status in a cohort of Italian normal weight and overweight male children. 108 boys enrolled in an andrological health prevention project underwent physical examination, anthropometric measurements, and fasting blood sampling. Serum blood glucose, HDL-cholesterol, triglycerides, parathyroid hormone, and 25-hydroxyvitamin D (25(OH)D) were measured. Cardiovascular risk factors were defined according to the National Cholesterol Education Program Adult Treatment Panel III modified for age. Lean and overweight subjects differed in terms of waist circumference (P < 0.001), HDL-cholesterol (P = 0.001), triglycerides (P = 0.001), systolic blood pressure (P < 0.001) and diastolic blood pressure (P = 0.002). Both groups had similar mean 25(OH)D levels (P = 0.160) and were below the sufficiency threshold: indeed only 24 % of normal weight had 25(OH)D ≥30 ng/ml, and even less in the overweight/obese group (8 %, P = 0.03 vs. normal weight). A significant accumulation of risk factors in course of 25(OH)D insufficiency was detected in both the whole cohort and in the normal weight group (P = 0.003 and P = 0.04, respectively) with odd ratios of 1.31 (1.16-1.49 95%CI) and 1.41 (1.18-1.69 95%CI), respectively. In course of vitamin D deficiency, the odd ratios were 2.24 (1.34-3.77 95%CI, P = 0.003) in the whole cohort and 2.40 (1.27-4.82 95%CI, P = 0.03) in lean subjects. We reported a considerable occurrence of cardiovascular risk factors in course of hypovitaminosis D in overweight/obese boys and even in lean subjects, which normally would not have been further evaluated by considering the sole BMI-related parameters. In this regard, 25(OH)D levels appear as a potential discriminating parameter able to identify male children at higher health risk.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 15%
Other 3 8%
Researcher 2 5%
Student > Postgraduate 2 5%
Student > Doctoral Student 2 5%
Other 8 20%
Unknown 17 43%
Readers by discipline Count As %
Medicine and Dentistry 8 20%
Nursing and Health Professions 6 15%
Biochemistry, Genetics and Molecular Biology 3 8%
Agricultural and Biological Sciences 1 3%
Unspecified 1 3%
Other 2 5%
Unknown 19 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2015.
All research outputs
#15,345,593
of 22,826,360 outputs
Outputs from Endocrine
#946
of 1,684 outputs
Outputs of similar age
#156,583
of 266,863 outputs
Outputs of similar age from Endocrine
#11
of 27 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,684 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,863 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.