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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ATM functions at the peroxisome to induce pexophagy in response to ROS
|
|---|---|
| Published in |
Nature Cell Biology, September 2015
|
| DOI | 10.1038/ncb3230 |
| Pubmed ID | |
| Authors |
Jiangwei Zhang, Durga Nand Tripathi, Ji Jing, Angela Alexander, Jinhee Kim, Reid T. Powell, Ruhee Dere, Jacqueline Tait-Mulder, Ji-Hoon Lee, Tanya T. Paull, Raj K. Pandita, Vijaya K. Charaka, Tej K. Pandita, Michael B. Kastan, Cheryl Lyn Walker |
| Abstract |
Peroxisomes are highly metabolic, autonomously replicating organelles that generate reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells must maintain peroxisome homeostasis, or risk pathologies associated with too few peroxisomes, such as peroxisome biogenesis disorders, or too many peroxisomes, inducing oxidative damage and promoting diseases such as cancer. We report that the PEX5 peroxisome import receptor binds ataxia-telangiectasia mutated (ATM) and localizes this kinase to the peroxisome. In response to ROS, ATM signalling activates ULK1 and inhibits mTORC1 to induce autophagy. Specificity for autophagy of peroxisomes (pexophagy) is provided by ATM phosphorylation of PEX5 at Ser 141, which promotes PEX5 monoubiquitylation at Lys 209, and recognition of ubiquitylated PEX5 by the autophagy adaptor protein p62, directing the autophagosome to peroxisomes to induce pexophagy. These data reveal an important new role for ATM in metabolism as a sensor of ROS that regulates pexophagy. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Sweden | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 309 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Unknown | 305 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 73 | 24% |
| Researcher | 59 | 19% |
| Student > Master | 31 | 10% |
| Student > Bachelor | 23 | 7% |
| Student > Doctoral Student | 15 | 5% |
| Other | 37 | 12% |
| Unknown | 71 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 105 | 34% |
| Agricultural and Biological Sciences | 73 | 24% |
| Medicine and Dentistry | 19 | 6% |
| Neuroscience | 12 | 4% |
| Immunology and Microbiology | 5 | 2% |
| Other | 18 | 6% |
| Unknown | 77 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2021.
All research outputs
#1,823,092
of 22,826,360 outputs
Outputs from Nature Cell Biology
#940
of 3,823 outputs
Outputs of similar age
#26,326
of 267,706 outputs
Outputs of similar age from Nature Cell Biology
#22
of 49 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,823 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.1. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,706 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.