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Antifungal activity of linalool in cases of Candida spp. isolated from individuals with oral candidiasis

Overview of attention for article published in Brazilian journal of biology = Revista brasleira de biologia, September 2017
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Title
Antifungal activity of linalool in cases of Candida spp. isolated from individuals with oral candidiasis
Published in
Brazilian journal of biology = Revista brasleira de biologia, September 2017
DOI 10.1590/1519-6984.171054
Pubmed ID
Authors

I. J. Dias, E. R. I. S. Trajano, R. D. Castro, G. L. S. Ferreira, H. C. M. Medeiros, D. Q. C. Gomes

Abstract

This study analyzed the antifungal activity of phytoconstituents from linalool on Candida spp. strains, in vitro, isolated from patients with clinical diagnoses of oral candidiasis associated with the use of a dental prosthesis. Biological samples were collected from 12 patients using complete dentures or removable partial dentures and who presented mucous with diffuse erythematous or stippled features, indicating a clinical diagnosis of candidiasis. To identify fungal colonies of the genus Candida, samples were plated onto CHROMagar Candida®. The antifungal activity of linalool, a monoterpene unsaturated constituent of basil oil, was performed using the broth microdilution technique. Then, the minimum inhibitory concentration (MIC), the two subsequent stronger concentrations and the positive controls were subcultured on Sabouraud Dextrose Agar plates to determine the minimum fungicidal concentration (MFC). The experiments were performed in triplicate and nystatin was used as a positive control in all tests. Diagnoses of oral candidiasis were verified in eight patients (66.6%) and the most prevalent fungal species was Candida albicans (37.5%), followed by Candida krusei (25.0%); and Candida tropicalis (4.2%). The best antifungal activity of linalool was observed on Candida tropicalis (MIC = 500 mg/mL), followed by Candida albicans (MIC = 1.000 mg/mL), and Candida krusei (MIC = 2.000 mg/mL).Under the study conditions and based on the results obtained, it can be concluded that the Candida strains tested were susceptible to linalool.

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Geographical breakdown

Country Count As %
Unknown 56 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 23%
Student > Master 9 16%
Student > Ph. D. Student 5 9%
Student > Postgraduate 4 7%
Researcher 4 7%
Other 6 11%
Unknown 15 27%
Readers by discipline Count As %
Medicine and Dentistry 13 23%
Biochemistry, Genetics and Molecular Biology 10 18%
Pharmacology, Toxicology and Pharmaceutical Science 5 9%
Agricultural and Biological Sciences 5 9%
Chemistry 4 7%
Other 4 7%
Unknown 15 27%