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The Prognostic Impact of a Positive Vascular Margin on pT3 Clear Cell Renal Cell Carcinoma

Overview of attention for article published in The Journal of Urology, February 2016
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  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

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4 tweeters

Citations

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12 Dimensions

Readers on

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19 Mendeley
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Title
The Prognostic Impact of a Positive Vascular Margin on pT3 Clear Cell Renal Cell Carcinoma
Published in
The Journal of Urology, February 2016
DOI 10.1016/j.juro.2015.08.099
Pubmed ID
Authors

Nick W. Liu, James D. Wren, Emily Vertosick, Justin K. Lee, Nicholas E. Power, Nicole E. Benfante, Simon Y. Kimm, Manjit S. Bains, Daniel D. Sjoberg, Paul Russo, Jonathan A. Coleman

Abstract

We examined the impact of positive vascular margins in patients with pT3 clear cell renal cell carcinoma. After excluding patients with non-vascular positive margins, metastasis, lymph node involvement, neoadjuvant therapy, or non-clear cell histology, we identified 224 patients with venous tumor invasion through our institutional database from 1999-2013. Kaplan-Meier analysis and log rank tests were used to evaluate whether positive vascular margins were associated with progression-free survival or cancer-specific survival. Forty-one patients (18%) had a positive vascular margin. Margin status was directly related to the level of invasion (p <0.0001). Compared to the negative vascular margin group, the positive group had significantly worse progression-free survival (p=0.01), but not cancer-specific survival (p=0.3). Similarly, level of vascular thrombus invasion was significantly associated with worse progression-free survival (p=0.02), but not cancer-specific survival (p=0.4). Three-year progression-free survival was worst with inferior vena cava invasion and best with segmental/muscular venous branch invasion (54% [95% CI 34-70] vs. 76% [95% CI 64-85]). Among patients with only main renal vein thrombus, vascular margin status was not associated with progression-free survival (p=0.5) or cancer-specific survival (p=0.2). In patients with pT3N0/XM0 clear cell renal cell carcinoma, positive vascular margins are associated with risk for disease progression. However, the risk of relapse associated with positive vascular margin is driven by extent of vascular thrombus invasion. These findings suggest that the clinical significance of vascular margin status as currently defined in pT3 clear cell renal cell carcinoma is minimal.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 4 21%
Other 3 16%
Student > Doctoral Student 2 11%
Researcher 2 11%
Professor 1 5%
Other 3 16%
Unknown 4 21%
Readers by discipline Count As %
Medicine and Dentistry 11 58%
Agricultural and Biological Sciences 2 11%
Computer Science 1 5%
Arts and Humanities 1 5%
Unknown 4 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2015.
All research outputs
#9,279,308
of 16,140,942 outputs
Outputs from The Journal of Urology
#8,358
of 14,376 outputs
Outputs of similar age
#108,322
of 242,845 outputs
Outputs of similar age from The Journal of Urology
#146
of 362 outputs
Altmetric has tracked 16,140,942 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,376 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,845 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 362 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.