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Challenging Mycobacterium tuberculosis dormancy mechanisms and their immunodiagnostic potential

Overview of attention for article published in Brazilian Journal of Infectious Diseases, November 2015
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1 tweeter

Citations

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Readers on

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66 Mendeley
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Title
Challenging Mycobacterium tuberculosis dormancy mechanisms and their immunodiagnostic potential
Published in
Brazilian Journal of Infectious Diseases, November 2015
DOI 10.1016/j.bjid.2015.08.004
Pubmed ID
Authors

Alexandre Silva Chaves, Michele Fernandes Rodrigues, Ana Márcia Menezes Mattos, Henrique Couto Teixeira

Abstract

Mycobacterium tuberculosis is the etiologic agent of tuberculosis, one of the world's greatest cause of morbidity and mortality due to infectious disease. Many evolutionary mechanisms have contributed to its high level of adaptation as a host pathogen. Prior to become dormant, a group of about 50 genes related to metabolic changes are transcribed by the DosR regulon, one of the most complex and important systems of host-pathogen interaction. This genetic mechanism allows the mycobacteria to persist during long time periods, establishing the so-called latent infection. Even in the presence of a competent immune response, the host cannot eliminate the pathogen, only managing to keep it surrounded by an unfavorable microenvironment for its growth. However, conditions such as immunosuppression may reestablish optimal conditions for bacterial growth, culminating in the onset of active disease. The interactions between the pathogen and its host are still not completely elucidated. Nonetheless, many studies are being carried out in order to clarify this complex relationship, thus creating new possibilities for patient approach and laboratory screening.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Brazil 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 29%
Researcher 10 15%
Student > Bachelor 10 15%
Student > Master 9 14%
Professor > Associate Professor 4 6%
Other 9 14%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 18%
Biochemistry, Genetics and Molecular Biology 12 18%
Immunology and Microbiology 11 17%
Medicine and Dentistry 10 15%
Social Sciences 4 6%
Other 11 17%
Unknown 6 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2016.
All research outputs
#13,935,912
of 15,801,576 outputs
Outputs from Brazilian Journal of Infectious Diseases
#361
of 475 outputs
Outputs of similar age
#199,176
of 243,080 outputs
Outputs of similar age from Brazilian Journal of Infectious Diseases
#7
of 9 outputs
Altmetric has tracked 15,801,576 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 475 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,080 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.