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X Demographics
Mendeley readers
| Title |
Stem cell‐derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy
|
|---|---|
| Published in |
Cancer Communications, September 2015
|
| DOI | 10.1186/s40880-015-0051-5 |
| Pubmed ID | |
| Authors |
Farah Fatima, Muhammad Nawaz |
| Abstract |
Stem cells are known to maintain stemness at least in part through secreted factors that promote stem-like phenotypes in resident cells. Accumulating evidence has clarified that stem cells release nano-vesicles, known as exosomes, which may serve as mediators of cell-to-cell communication and may potentially transmit stem cell phenotypes to recipient cells, facilitating stem cell maintenance, differentiation, self-renewal, and repair. It has become apparent that stem cell-derived exosomes mediate interactions among stromal elements, promote genetic instability in recipient cells, and induce malignant transformation. This review will therefore discuss the potential of stem cell-derived exosomes in the context of stromal remodeling and their ability to generate cancer-initiating cells in a tumor niche by inducing morphologic and functional differentiation of fibroblasts into tumor-initiating fibroblasts. In addition, the immunosuppressive potential of stem cell-derived exosomes in cancer immunotherapy and their prospective applications in cell-free therapies in future translational medicine is discussed. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 25% |
| Austria | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | <1% |
| United States | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 131 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 25% |
| Student > Master | 26 | 19% |
| Researcher | 19 | 14% |
| Student > Bachelor | 11 | 8% |
| Student > Doctoral Student | 5 | 4% |
| Other | 16 | 12% |
| Unknown | 24 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 36 | 27% |
| Agricultural and Biological Sciences | 28 | 21% |
| Medicine and Dentistry | 23 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Engineering | 3 | 2% |
| Other | 13 | 10% |
| Unknown | 27 | 20% |