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Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents

Overview of attention for article published in Scientific Reports, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

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1 news outlet
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2 X users
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1 patent
facebook
1 Facebook page

Citations

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60 Dimensions

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74 Mendeley
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Title
Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents
Published in
Scientific Reports, September 2015
DOI 10.1038/srep14046
Pubmed ID
Authors

Ao Guo, Dongming He, Hong-Bo Xu, Chang-An Geng, Jian Zhao

Abstract

Regulatory T cells (Treg) play a critical role to control immune responses and to prevent autoimmunity, thus selective increase of Treg cells in vivo has broad therapeutic implications for autoimmune and inflammatory diseases. Licorice is a well-known herbal medicine used worldwide for over thousands of years, and accumulating evidence has shown its immunomodulatory potential. However, it is not clear whether licorice could regulate the induction and function of Treg cells. Here we found licorice extract could promote Treg cell induction, and then we used a rational approach to isolate its functional fractions and constituents. The results showed that two constituents, isoliquiritigenin and naringenin, promoted Treg cell induction both in vitro and in vivo. The effective fractions and two constituents of licorice also enhanced immune suppression of Treg cells, and they further reduced severity of DSS-induced colitis in mice. This study suggested that promotion of regulatory T cell induction could be an underlying mechanism of the historically and widely used herbal medicine licorice, providing its two effective molecules against autoimmune and inflammatory diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 4%
Poland 1 1%
Unknown 70 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 14%
Student > Master 10 14%
Student > Bachelor 7 9%
Student > Ph. D. Student 6 8%
Student > Doctoral Student 4 5%
Other 18 24%
Unknown 19 26%
Readers by discipline Count As %
Medicine and Dentistry 14 19%
Pharmacology, Toxicology and Pharmaceutical Science 9 12%
Immunology and Microbiology 9 12%
Agricultural and Biological Sciences 4 5%
Biochemistry, Genetics and Molecular Biology 4 5%
Other 8 11%
Unknown 26 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2017.
All research outputs
#1,874,881
of 23,577,654 outputs
Outputs from Scientific Reports
#17,150
of 127,511 outputs
Outputs of similar age
#26,608
of 270,223 outputs
Outputs of similar age from Scientific Reports
#293
of 2,139 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 127,511 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,223 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 2,139 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.