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Clinical characteristics and antimicrobial susceptibility of Bacillus cereus blood stream infections

Overview of attention for article published in Annals of Clinical Microbiology and Antimicrobials, September 2015
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Title
Clinical characteristics and antimicrobial susceptibility of Bacillus cereus blood stream infections
Published in
Annals of Clinical Microbiology and Antimicrobials, September 2015
DOI 10.1186/s12941-015-0104-2
Pubmed ID
Authors

Mahoko Ikeda, Yuka Yagihara, Keita Tatsuno, Mitsuhiro Okazaki, Shu Okugawa, Kyoji Moriya

Abstract

Bacillus cereus is one of the pathogens causing nosocomial bloodstream infections (BSIs). However, few reports have documented the antimicrobial susceptibility and clinical characteristics of Bacillus cereus BSI and the importance of empirical therapy. The aim of this study was to investigate the clinical characteristics and antimicrobial susceptibility of B. cereus isolates from patients with BSI and to analyze the impact of appropriate empirical therapy on the outcome of patients with B. cereus BSI. All adult cases of bacteremia between April 2003 and March 2012 in a teaching hospital in Tokyo, Japan were reviewed retrospectively. Clinical data were collected from the patients' medical records and charts. Antimicrobial susceptibility testing was performed by broth microdilution method. The patients with B. cereus BSI were divided into an appropriate empirical therapy group and an inappropriate empirical therapy group. The primary outcome was all-cause mortality at 4 weeks after the start of BSI. The secondary outcome was early defervescence within 2 days after starting empirical therapy. There were 29 B. cereus bloodstream infection cases. No vancomycin, gentamicin, and imipenem-resistant isolates were found. However, 65.5 % were resistant to clindamycin and 10.3 % were resistant to levofloxacin. The main etiology was venous catheter-related (69 %). All-cause mortality at 4 weeks was not significantly different between the appropriate empirical therapy group (9 cases) and the inappropriate group (20 cases) in this study. However, early defervescence within 2 days after starting empirical therapy was significantly different (p = 0.032). The BSI of B. cereus is mostly caused by venous catheter-related infections. Appropriate empirical therapy is important to achieve early clinical resolution in B. cereus BSI. Vancomycin is one of the appropriate selections of empirical therapy for B. cereus BSI.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 144 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 22 15%
Student > Master 15 10%
Other 12 8%
Researcher 12 8%
Student > Postgraduate 11 8%
Other 29 20%
Unknown 43 30%
Readers by discipline Count As %
Medicine and Dentistry 30 21%
Immunology and Microbiology 18 13%
Agricultural and Biological Sciences 16 11%
Biochemistry, Genetics and Molecular Biology 16 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 12 8%
Unknown 48 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2019.
All research outputs
#14,238,195
of 22,828,180 outputs
Outputs from Annals of Clinical Microbiology and Antimicrobials
#286
of 608 outputs
Outputs of similar age
#139,038
of 268,887 outputs
Outputs of similar age from Annals of Clinical Microbiology and Antimicrobials
#4
of 6 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 608 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,887 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.