Title |
Pneumococcal Conjugate Vaccine impact assessment in Bangladesh
|
---|---|
Published in |
Gates Open Research, April 2018
|
DOI | 10.12688/gatesopenres.12805.1 |
Pubmed ID | |
Authors |
Abdullah H Baqui, Eric D McCollum, Samir K Saha, Arun K Roy, Nabidul H Chowdhury, Meagan Harrison, Abu Abdullah Mohammad Hanif, Nicole Simmons, Arif Mahmud, Nazma Begum, Salahuddin Ahmed, Ahad M Khan, Zabed Bin Ahmed, Maksuda Islam, Dipak Mitra, Abdul Quaiyum, Miguel A Chavez, Farhan Pervaiz, Catherine H Miele, Holly B Schuh, Rasheda Khanam, William Checkley, Lawrence H Moulton, Mathuram Santosham |
Abstract |
The study examines the impact of the introduction of 10-valent Pneumococcal Conjugate Vaccine (PCV10) into Bangladesh's national vaccine program. PCV10 is administered to children under 1 year-old; the scheduled ages of administration are at 6, 10, and 18 weeks. The study is conducted in ~770,000 population containing ~90,000 <5 children in Sylhet, Bangladesh and has five objectives: 1) To collect data on community-based pre-PCV incidence rates of invasive pneumococcal diseases (IPD) in 0-59 month-old children in Sylhet, Bangladesh; 2) To evaluate the effectiveness of PCV10 introduction on Vaccine Type (VT) IPD in 3-59 month-old children using an incident case-control study design. Secondary aims include measuring the effects of PCV10 introduction on all IPD in 3-59 month-old children using case-control study design, and quantifying the emergence of Non Vaccine Type IPD; 3) To evaluate the effectiveness of PCV10 introduction on chest radiograph-confirmed pneumonia in children 3-35 months old using incident case-control study design. We will estimate the incidence trend of clinical and radiologically-confirmed pneumonia in 3-35 month-old children in the study area before and after introduction of PCV10; 4) To determine the feasibility and utility of lung ultrasound for the diagnosis of pediatric pneumonia in a large sample of children in a resource-limited setting. We will also evaluate the effectiveness of PCV10 introduction on ultrasound-confirmed pneumonia in 3-35 month-old children using an incident case-control design and to examine the incidence trend of ultrasound-confirmed pneumonia in 3-35 month-old children in the study area before and after PCV10 introduction; and 5) To determine the direct and indirect effects of vaccination status on nasopharyngeal colonization on VT pneumococci among children with pneumonia . This paper presents the methodology. The study will allow us to conduct a comprehensive and robust assessment of the impact of national introduction of PCV10 on pneumococcal disease in Bangladesh. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 67% |
India | 1 | 11% |
Bangladesh | 1 | 11% |
Unknown | 1 | 11% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 56% |
Practitioners (doctors, other healthcare professionals) | 4 | 44% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 17% |
Student > Master | 5 | 10% |
Student > Ph. D. Student | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Other | 3 | 6% |
Other | 6 | 13% |
Unknown | 19 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 23% |
Immunology and Microbiology | 3 | 6% |
Nursing and Health Professions | 2 | 4% |
Social Sciences | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 5 | 10% |
Unknown | 24 | 50% |