Title |
Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus
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Published in |
Marine Drugs, July 2018
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DOI | 10.3390/md16070229 |
Pubmed ID | |
Authors |
Dong-Lan Wu, Hou-Jin Li, Duncan R. Smith, Janejira Jaratsittisin, Xia-Fu-Kai-Ti Xia-Ke-Er, Wen-Zhe Ma, Yong-Wei Guo, Jun Dong, Juan Shen, De-Po Yang, Wen-Jian Lan |
Abstract |
In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 30 | 100% |
Demographic breakdown
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Researcher | 5 | 17% |
Student > Master | 4 | 13% |
Student > Ph. D. Student | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Student > Bachelor | 2 | 7% |
Other | 3 | 10% |
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Chemical Engineering | 1 | 3% |
Other | 1 | 3% |
Unknown | 10 | 33% |