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Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons

Overview of attention for article published in Acta Neuropathologica Communications, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

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1 news outlet
twitter
2 tweeters

Citations

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38 Dimensions

Readers on

mendeley
45 Mendeley
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1 CiteULike
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Title
Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons
Published in
Acta Neuropathologica Communications, September 2015
DOI 10.1186/s40478-015-0236-9
Pubmed ID
Authors

Hiroyuki Sumikura, Masaki Takao, Hiroyuki Hatsuta, Shinji Ito, Yuta Nakano, Akiko Uchino, Akane Nogami, Yuko Saito, Hideki Mochizuki, Shigeo Murayama

Abstract

Lewy body-related α-synucleinopathy (LBAS, the abnormal accumulation of pathologic α-synuclein) is found in the central and peripheral nervous systems, including the spinal cord, dorsal root ganglia, and sympathetic ganglia, of Parkinson's disease patients. However, few studies have focused on the distribution of LBAS in the spinal cord, primary sensory neurons, and preganglionic sympathetic nerves. We analyzed 265 consecutive subjects with LBAS who underwent autopsy at a general geriatric hospital. LBAS in the spinal cord was significantly associated with that in the lower brainstem regions that are directly connected to the spinal cord (i.e., the medullary reticular formation and locus ceruleus), but it was not associated with the olfactory bulb-amygdala system, which is not directly connected to the spinal cord, suggesting that the lower brainstem is a key structure regarding the spread of LBAS to the spinal cord. In the primary sensory neurons, most subjects with LBAS in the dorsal root ganglia had LBAS in the dorsal root, and all subjects with LBAS in the dorsal root also had LBAS in the dorsal horn, suggesting that LBAS spreads retrogradely from the axonal terminals of the dorsal horn to the somata of the dorsal root ganglia via the dorsal root. In the preganglionic sympathetic nerves, the LBAS in the sympathetic ganglia preceded that in the nucleus of the intermediolateral column of the thoracic cord, suggesting that LBAS spreads retrogradely through the preganglionic sympathetic nerves. LBAS in the spinal cord was associated with the lower regions of the brainstem, but not with the olfactory bulb or amygdala. LBAS may spread centrifugally along the primary sensory neurons, whereas it may spread centripetally along the preganglionic sympathetic nerves.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 24%
Student > Ph. D. Student 7 16%
Student > Master 4 9%
Professor > Associate Professor 3 7%
Professor 3 7%
Other 9 20%
Unknown 8 18%
Readers by discipline Count As %
Medicine and Dentistry 10 22%
Neuroscience 8 18%
Biochemistry, Genetics and Molecular Biology 7 16%
Agricultural and Biological Sciences 6 13%
Psychology 3 7%
Other 2 4%
Unknown 9 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2015.
All research outputs
#532,391
of 6,242,159 outputs
Outputs from Acta Neuropathologica Communications
#53
of 309 outputs
Outputs of similar age
#26,787
of 188,200 outputs
Outputs of similar age from Acta Neuropathologica Communications
#6
of 15 outputs
Altmetric has tracked 6,242,159 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 309 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,200 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.