Title |
An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a
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Published in |
Cell Death & Disease, July 2018
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DOI | 10.1038/s41419-018-0777-5 |
Pubmed ID | |
Authors |
Jason T. Serviss, Nathanael Andrews, Jimmy Van den Eynden, Felix Clemens Richter, Miranda Houtman, Mattias Vesterlund, Laura Schwarzmueller, Per Johnsson, Erik Larsson, Dan Grandér †, Katja Pokrovskaja Tamm |
Abstract |
The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct downstream target of TP53 with roles in several pathways associated with oncogenesis, such as proliferation, cellular growth, and differentiation. Due to its broad tumor suppressive activity, it is not surprising that miR34a expression is altered in a wide variety of solid tumors and hematological malignancies. However, the mechanisms by which miR34a is regulated in these cancers is largely unknown. In this study, we find that a long noncoding RNA transcribed antisense to the miR34a host gene, is critical for miR34a expression and mediation of its cellular functions in multiple types of human cancer. We name this long noncoding RNA lncTAM34a, and characterize its ability to facilitate miR34a expression under different types of cellular stress in both TP53-deficient and wild-type settings. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Switzerland | 1 | 33% |
Sweden | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 33% |
Student > Ph. D. Student | 3 | 17% |
Student > Doctoral Student | 2 | 11% |
Student > Bachelor | 2 | 11% |
Other | 1 | 6% |
Other | 2 | 11% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 22% |
Agricultural and Biological Sciences | 2 | 11% |
Immunology and Microbiology | 1 | 6% |
Neuroscience | 1 | 6% |
Other | 1 | 6% |
Unknown | 3 | 17% |