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Quantitative performance of 124I PET/MR of neck lesions in thyroid cancer patients using 124I PET/CT as reference

Overview of attention for article published in EJNMMI Physics, July 2018
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Title
Quantitative performance of 124I PET/MR of neck lesions in thyroid cancer patients using 124I PET/CT as reference
Published in
EJNMMI Physics, July 2018
DOI 10.1186/s40658-018-0214-y
Pubmed ID
Authors

Walter Jentzen, Jinda Phaosricharoen, Benedikt Gomez, Philipp Hetkamp, Vanessa Stebner, Ina Binse, Sonja Kinner, Ken Herrmann, Amir Sabet, James Nagarajah

Abstract

In patients with differentiated thyroid cancer (DTC), serial 124I PET/CT imaging is, for instance, used to assess the absorbed (radiation) dose to lesions. Frequently, the lesions are located in the neck and they are close to or surrounded by different tissue types. In contrast to PET/CT, MR-based attenuation correction in PET/MR may be therefore challenging in the neck region. The aim of this retrospective study was to assess the quantitative performance of 124I PET/MRI of neck lesions by comparing the MR-based and CT-based 124I activity concentrations (ACs). Sixteen DTC patients underwent PET/CT scans at 24 and 120 h after administration of about 25 MBq 124I. Approximately 1 h before or after PET/CT examination, each patient additionally received a 24-h PET/MR scan and sometimes a 120-h PET/MR scan. PET images were reconstructed using the respective attenuation correction approach. Appropriate reconstruction parameters and corrections were used to harmonize the reconstructed PET images to provide, for instance, similar spatial resolution. For each lesion, two types of ACs were ascertained: the maximum AC (max-AC) and an average AC (avg-AC). The avg-AC is the average activity concentration obtained within a spherical volume of interest with a diameter of 7 mm, equaling the PET scanner resolution. For each type of AC, the percentage AC difference between MR-based and CT-based ACs was determined and Lin's concordance correlation analysis was applied. Quantitative performance was considered acceptable if the standard deviation was ± 25% (precision), and the mean value was within ± 10% (accuracy). The avg-ACs (max-ACs within parentheses) of 74 lesions ranged from 0.20 (0.33) to 657 (733) kBq/mL. Excluding two lesions with ACs of approximately 1 kBq/mL, the mean (median) ± standard deviation (range) was - 4% (- 5%) ± 14% (- 28 to 29%) for the avg-AC and - 9% (- 11%) ± 14% (- 33 to 33%) for the max-AC. Lin's concordance correlation coefficients were ≥ 0.97, indicating substantial AC agreement. Quantification of lesions in the neck region using 124I PET/MR showed acceptable quantitation performance to 124I PET/CT for AC above 1 kBq/mL. The PET/MRI-based 124I ACs in the neck region can be therefore reliably used in pre-therapy dosimetry planning.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 25%
Student > Bachelor 3 25%
Researcher 2 17%
Other 1 8%
Student > Master 1 8%
Other 1 8%
Unknown 1 8%
Readers by discipline Count As %
Medicine and Dentistry 3 25%
Neuroscience 2 17%
Physics and Astronomy 1 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Immunology and Microbiology 1 8%
Other 1 8%
Unknown 3 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2018.
All research outputs
#8,281,591
of 13,266,991 outputs
Outputs from EJNMMI Physics
#25
of 60 outputs
Outputs of similar age
#159,096
of 268,301 outputs
Outputs of similar age from EJNMMI Physics
#1
of 1 outputs
Altmetric has tracked 13,266,991 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 60 research outputs from this source. They receive a mean Attention Score of 2.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,301 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them