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Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach

Overview of attention for article published in Stem Cell Research & Therapy, September 2015
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2 tweeters

Citations

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8 Dimensions

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25 Mendeley
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Title
Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach
Published in
Stem Cell Research & Therapy, September 2015
DOI 10.1186/s13287-015-0157-3
Pubmed ID
Authors

Cindy Leten, Jesse Trekker, Tom Struys, Tom Dresselaers, Rik Gijsbers, Greetje Vande Velde, Ivo Lambrichts, Annemie Van Der Linden, Catherine M. Verfaillie, Uwe Himmelreich

Abstract

In this study, we planned to assess if adult stem cell-based suicide gene therapy can efficiently eliminate glioblastoma cells in vivo. We investigated the therapeutic potential of mouse Oct4(-) bone marrow multipotent adult progenitor cells (mOct4(-) BM-MAPCs) in a mouse glioblastoma model, guided by multimodal in vivo imaging methods to identify therapeutic windows. Magnetic resonance imaging (MRI) of animals, wherein 5 × 10(5) syngeneic enhanced green fluorescent protein-firefly luciferase-herpes simplex virus thymidine kinase (eGFP-fLuc-HSV-TK) expressing and superparamagnetic iron oxide nanoparticle labeled (1 % or 10 %) mOct4(-) BM-MAPCs were grafted in glioblastoma (GL261)-bearing animals, showed that labeled mOct4(-) BM-MAPCs were located in and in close proximity to the tumor. Subsequently, ganciclovir (GCV) treatment was commenced and the fate of both the MAPCs and the tumor were followed by multimodal imaging (MRI and bioluminescence imaging). In the majority of GCV-treated, but not phosphate-buffered saline-treated animals, a significant difference was found in mOct4(-) BM-MAPC viability and tumor size at the end of treatment. Noteworthy, in some phosphate-buffered saline-treated animals (33 %), a significant decrease in tumor size was seen compared to sham-operated animals, which could potentially also be caused by a synergistic effect of the immune-modulatory stem cells. Suicide gene therapy using mOct4(-) BM-MAPCs as cellular carriers was effective in reducing the tumor size in the majority of the GCV-treated animals leading to a longer progression-free survival compared to sham-operated animals. This treatment could be followed and guided noninvasively in vivo by MRI and bioluminescence imaging. Noninvasive imaging is of particular interest for a rapid and efficient validation of stem cell-based therapeutic approaches for glioblastoma and hereby contributes to a better understanding and optimization of a promising therapeutic approach for glioblastoma patients.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 20%
Student > Bachelor 4 16%
Other 3 12%
Researcher 3 12%
Student > Master 2 8%
Other 4 16%
Unknown 4 16%
Readers by discipline Count As %
Medicine and Dentistry 5 20%
Agricultural and Biological Sciences 4 16%
Biochemistry, Genetics and Molecular Biology 3 12%
Nursing and Health Professions 2 8%
Social Sciences 1 4%
Other 6 24%
Unknown 4 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2015.
All research outputs
#2,813,098
of 6,386,702 outputs
Outputs from Stem Cell Research & Therapy
#274
of 509 outputs
Outputs of similar age
#98,153
of 200,601 outputs
Outputs of similar age from Stem Cell Research & Therapy
#27
of 61 outputs
Altmetric has tracked 6,386,702 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 509 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,601 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.