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Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells

Overview of attention for article published in Clinical and Translational Allergy, July 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#21 of 474)
  • High Attention Score compared to outputs of the same age (91st percentile)

Mentioned by

twitter
47 tweeters
facebook
2 Facebook pages

Citations

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12 Dimensions

Readers on

mendeley
49 Mendeley
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Title
Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells
Published in
Clinical and Translational Allergy, July 2018
DOI 10.1186/s13601-018-0213-z
Pubmed ID
Authors

Jiayun Hu, Jiajie Chen, Lanlan Ye, Zelang Cai, Jinlu Sun, Kunmei Ji

Abstract

Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators. Among them, IgE plays a vital role in the development of acute allergic reactions and chronic inflammatory allergic diseases, making its control particularly important in the treatment of IgE-mediated allergic diseases. This review provides an overview of the current state of IgE targeted therapy development, focusing on three areas of translational research: IgE neutralization in blood; IgE-effector cell elimination; and IgE+ B cell reduction. IgE-targeted medicines such as FDA approved drug Xolair (Omalizumab) represent a promising avenue for treating IgE-mediated allergic diseases given the pernicious role of IgE in disease progression. Additionally, targeted therapy for IgE-mediated allergic diseases may be advanced through cellular treatments, including the modification of effector cells.

Twitter Demographics

The data shown below were collected from the profiles of 47 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 27%
Student > Master 6 12%
Other 5 10%
Student > Ph. D. Student 4 8%
Student > Doctoral Student 4 8%
Other 10 20%
Unknown 7 14%
Readers by discipline Count As %
Medicine and Dentistry 12 24%
Biochemistry, Genetics and Molecular Biology 9 18%
Immunology and Microbiology 8 16%
Agricultural and Biological Sciences 6 12%
Chemical Engineering 2 4%
Other 6 12%
Unknown 6 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2020.
All research outputs
#777,304
of 15,518,441 outputs
Outputs from Clinical and Translational Allergy
#21
of 474 outputs
Outputs of similar age
#24,613
of 278,028 outputs
Outputs of similar age from Clinical and Translational Allergy
#1
of 2 outputs
Altmetric has tracked 15,518,441 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 474 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,028 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them