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Proteomics analysis after traumatic brain injury in rats: the search for potential biomarkers

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, April 2015
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Title
Proteomics analysis after traumatic brain injury in rats: the search for potential biomarkers
Published in
Arquivos de Neuro-Psiquiatria, April 2015
DOI 10.1590/0004-282x20150006
Pubmed ID
Authors

Jun Ding, Zhengang Ding, Fang Yuan, Jianyi Guo, Hao Chen, Wenwei Gao, Ren Wang, Yi Gu, Jiong Chen, Yan Guo, Hengli Tian

Abstract

Many studies of protein expression after traumatic brain injury (TBI) have identified biomarkers for diagnosing or determining the prognosis of TBI. In this study, we searched for additional protein markers of TBI using a fluid perfusion impact device to model TBI in S-D rats. Two-dimensional gel electrophoresis and mass spectrometry were used to identify differentially expressed proteins. After proteomic analysis, we detected 405 and 371 protein spots within a pH range of 3-10 from sham-treated and contused brain cortex, respectively. Eighty protein spots were differentially expressed in the two groups and 20 of these proteins were identified. This study validated the established biomarkers of TBI and identified potential biomarkers that could be examined in future work.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 33%
Researcher 3 20%
Student > Ph. D. Student 3 20%
Professor 2 13%
Other 1 7%
Other 1 7%
Readers by discipline Count As %
Medicine and Dentistry 4 27%
Biochemistry, Genetics and Molecular Biology 3 20%
Neuroscience 3 20%
Nursing and Health Professions 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Other 1 7%
Unknown 2 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2015.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#1,140
of 1,368 outputs
Outputs of similar age
#240,617
of 279,170 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#30
of 39 outputs
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