Title |
Proteomics analysis after traumatic brain injury in rats: the search for potential biomarkers
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Published in |
Arquivos de Neuro-Psiquiatria, April 2015
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DOI | 10.1590/0004-282x20150006 |
Pubmed ID | |
Authors |
Jun Ding, Zhengang Ding, Fang Yuan, Jianyi Guo, Hao Chen, Wenwei Gao, Ren Wang, Yi Gu, Jiong Chen, Yan Guo, Hengli Tian |
Abstract |
Many studies of protein expression after traumatic brain injury (TBI) have identified biomarkers for diagnosing or determining the prognosis of TBI. In this study, we searched for additional protein markers of TBI using a fluid perfusion impact device to model TBI in S-D rats. Two-dimensional gel electrophoresis and mass spectrometry were used to identify differentially expressed proteins. After proteomic analysis, we detected 405 and 371 protein spots within a pH range of 3-10 from sham-treated and contused brain cortex, respectively. Eighty protein spots were differentially expressed in the two groups and 20 of these proteins were identified. This study validated the established biomarkers of TBI and identified potential biomarkers that could be examined in future work. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 33% |
Researcher | 3 | 20% |
Student > Ph. D. Student | 3 | 20% |
Professor | 2 | 13% |
Other | 1 | 7% |
Other | 1 | 7% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 27% |
Biochemistry, Genetics and Molecular Biology | 3 | 20% |
Neuroscience | 3 | 20% |
Nursing and Health Professions | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 13% |