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Noradrenergic System in Down Syndrome and Alzheimer's Disease A Target for Therapy.

Overview of attention for article published in Current Alzheimer Research, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)

Mentioned by

news
1 news outlet
twitter
1 tweeter

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
49 Mendeley
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Title
Noradrenergic System in Down Syndrome and Alzheimer's Disease A Target for Therapy.
Published in
Current Alzheimer Research, September 2015
Pubmed ID
Authors

Phillips, C, Fahimi, A, Das, D, Mojabi, F S, Ponnusamy, R, Salehi, A

Abstract

Locus coeruleus (LC) neurons in the brainstem send extensive noradrenergic (NE)-ergic terminals to the majority of brain regions, particularly those involved in cognitive function. Both Alzheimer's disease (AD) and Down syndrome (DS) are characterized by similar pathology including significant LC degeneration and dysfunction of the NE-ergic system. Extensive loss of NE-ergic terminals has been linked to alterations in brain regions vital for cognition, mood, and executive function. While the mechanisms by which NE-ergic abnormalities contribute to cognitive dysfunction are not fully understood, emergent evidence suggests that rescue of NE-ergic system can attenuate neuropathology and cognitive decline in both AD and DS. Therapeutic strategies to enhance NE neurotransmission have undergone limited testing. Among those deployed to date are NE reuptake inhibitors, presynaptic α-adrenergic receptor antagonists, NE prodrugs, and β-adrenergic agonists. Here we examine alterations in the NE-ergic system in AD and DS and suggest that NE-ergic system rescue is a plausible treatment strategy for targeting cognitive decline in both disorders.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Netherlands 1 2%
Italy 1 2%
Unknown 46 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 27%
Researcher 8 16%
Student > Master 6 12%
Student > Bachelor 6 12%
Professor 6 12%
Other 8 16%
Unknown 2 4%
Readers by discipline Count As %
Neuroscience 10 20%
Agricultural and Biological Sciences 9 18%
Medicine and Dentistry 8 16%
Psychology 7 14%
Biochemistry, Genetics and Molecular Biology 3 6%
Other 6 12%
Unknown 6 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2015.
All research outputs
#1,231,807
of 11,420,953 outputs
Outputs from Current Alzheimer Research
#127
of 657 outputs
Outputs of similar age
#37,846
of 241,828 outputs
Outputs of similar age from Current Alzheimer Research
#16
of 27 outputs
Altmetric has tracked 11,420,953 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 657 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,828 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.