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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1
|
|---|---|
| Published in |
Human Genetics, September 2015
|
| DOI | 10.1007/s00439-015-1598-6 |
| Pubmed ID | |
| Authors |
Mathieu Lemire, Conghui Qu, Lenora W. M. Loo, Syed H. E. Zaidi, Hansong Wang, Sonja I. Berndt, Stéphane Bézieau, Hermann Brenner, Peter T. Campbell, Andrew T. Chan, Jenny Chang-Claude, Mengmeng Du, Christopher K. Edlund, Steven Gallinger, Robert W. Haile, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Lifang Hou, Li Hsu, Eric J. Jacobs, Mark A. Jenkins, Jihyoun Jeon, Sébastien Küry, Li Li, Noralane M. Lindor, Polly A. Newcomb, John D. Potter, Gad Rennert, Anja Rudolph, Robert E. Schoen, Fredrick R. Schumacher, Daniela Seminara, Gianluca Severi, Martha L. Slattery, Emily White, Michael O. Woods, Michelle Cotterchio, Loïc Le Marchand, Graham Casey, Stephen B. Gruber, Ulrike Peters, Thomas J. Hudson |
| Abstract |
Over 50 loci associated with colorectal cancer (CRC) have been uncovered by genome-wide association studies (GWAS). Identifying additional loci has the potential to help elucidate aspects of the underlying biological processes leading to better understanding of the pathogenesis of the disease. We re-evaluated a GWAS by excluding controls that have family history of CRC or personal history of colorectal polyps, as we hypothesized that their inclusion reduces power to detect associations. This is supported empirically and through simulations. Two-phase GWAS analysis was performed in a total of 16,517 cases and 14,487 controls. We identified rs17094983, a SNP associated with risk of CRC [p = 2.5 × 10(-10); odds ratio estimated by re-including all controls (OR) = 0.87, 95 % confidence interval (CI) 0.83-0.91; minor allele frequency (MAF) = 13 %]. Results were replicated in samples of African descent (1894 cases and 4703 controls; p = 0.01; OR = 0.86, 95 % CI 0.77-0.97; MAF = 16 %). Gene expression data in 195 colon adenocarcinomas and 59 normal colon tissues from two different studies revealed that this locus has genotypes that are associated with RTN1 (Reticulon 1) expression (p = 0.001), a protein-coding gene involved in survival and proliferation of cancer cells which is highly expressed in normal colon tissues but has significantly reduced expression in tumor cells (p = 1.3 × 10(-8)). |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 25% |
| Student > Ph. D. Student | 8 | 16% |
| Professor | 7 | 14% |
| Other | 4 | 8% |
| Student > Master | 4 | 8% |
| Other | 6 | 12% |
| Unknown | 9 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 25% |
| Biochemistry, Genetics and Molecular Biology | 10 | 20% |
| Agricultural and Biological Sciences | 7 | 14% |
| Nursing and Health Professions | 3 | 6% |
| Immunology and Microbiology | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 12 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2015.
All research outputs
#15,686,478
of 23,310,485 outputs
Outputs from Human Genetics
#2,564
of 2,980 outputs
Outputs of similar age
#162,337
of 275,801 outputs
Outputs of similar age from Human Genetics
#13
of 18 outputs
Altmetric has tracked 23,310,485 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,980 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,801 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.