Title |
Ongoing burden of disease and mortality from HIV/CMV coinfection in Africa in the antiretroviral therapy era
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Published in |
Frontiers in Microbiology, September 2015
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DOI | 10.3389/fmicb.2015.01016 |
Pubmed ID | |
Authors |
Emily Adland, Paul Klenerman, Philip Goulder, Philippa C. Matthews |
Abstract |
Human Cytomegalovirus (CMV) is a well-recognized pathogen in the context of HIV infection, but since the roll out of ART, clinical and scientific interest in the problem of HIV/CMV coinfection has diminished. However, CMV remains a significant cofactor in HIV disease, with an influence on HIV acquisition, disease progression, morbidity, and mortality. Disease manifestations may be a result of direct interplay between the two viruses, or may arise as a secondary consequence of immune dysregulation and systemic inflammation. The problem is most relevant when the rates of coinfection are high, most notably in sub-Saharan Africa, and in children at risk of acquiring both infections early in life. Understanding the interplay between these viruses and developing strategies to diagnose, treat and prevent CMV should be a priority. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Unknown | 204 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 42 | 20% |
Student > Master | 33 | 16% |
Student > Ph. D. Student | 25 | 12% |
Researcher | 19 | 9% |
Student > Postgraduate | 13 | 6% |
Other | 30 | 15% |
Unknown | 43 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 44 | 21% |
Biochemistry, Genetics and Molecular Biology | 39 | 19% |
Immunology and Microbiology | 29 | 14% |
Agricultural and Biological Sciences | 20 | 10% |
Nursing and Health Professions | 7 | 3% |
Other | 16 | 8% |
Unknown | 50 | 24% |