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Lung volume recruitment in a preterm pig model of lung immaturity

Overview of attention for article published in American Journal of Physiology: Lung Cellular & Molecular Physiology, November 2015
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2 tweeters

Citations

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9 Dimensions

Readers on

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14 Mendeley
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Title
Lung volume recruitment in a preterm pig model of lung immaturity
Published in
American Journal of Physiology: Lung Cellular & Molecular Physiology, November 2015
DOI 10.1152/ajplung.00292.2015
Pubmed ID
Authors

Esmond L. Arrindell, Ramesh Krishnan, Marie van der Merwe, Frank Caminita, Scott C. Howard, Jie Zhang, Randal K. Buddington

Abstract

A translational preterm pig model analogous to infants born at 28 weeks of gestation revealed that continuous positive airway pressure results in limited lung recruitment but does not prevent respiratory distress syndrome (RDS); whereas, assist-control + volume guarantee (AC+VG) ventilation improves recruitment, but can cause injury, highlighting the need for improved ventilation strategies. We determined whether airway pressure release ventilation (APRV) can be used to recruit the immature lungs of preterm pigs without injury. Spontaneously breathing pigs delivered at 89% of term (model for 28 week infants) were randomized to 24 hours of APRV (n=9) versus AC+VG with a tidal volume of 5ml/kg (n=10). Control pigs (n=36) were provided with supplemental oxygen by an open mask. Nutrition and fluid support was provided throughout the 24-hour period. All pigs supported with APRV and AC+VG survived 24 hours, compared to 62% of control pigs. APRV resulted in improved lung volume recruitment compared with AC+VG based on radiographs, lower PCO2 levels (44±2.9 vs 53±2.7 mm Hg, p=0.009) and lower FiO2 requirements (36±6 vs 44±11 %, p<0.001), and higher oxygenation index (5.1±1.5 vs 2.9±1.1, p=0.001). There were no differences between APRV and AC+VG pigs for heart rate, wet/dry lung mass, pro-inflammatory cytokines, or histopathologic markers of lung injury. Lung protective ventilation with APRV improved recruitment of alveoli of preterm lungs, enhanced development and maintenance of functional residual capacity without injury, and improved clinical outcomes relative to AC+VG. Long-term consequences of lung volume recruitment using APRV should be evaluated.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 7 50%
Researcher 3 21%
Student > Master 2 14%
Other 2 14%
Student > Postgraduate 1 7%
Other 0 0%
Readers by discipline Count As %
Unspecified 6 43%
Medicine and Dentistry 5 36%
Nursing and Health Professions 2 14%
Immunology and Microbiology 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2015.
All research outputs
#7,536,653
of 12,497,962 outputs
Outputs from American Journal of Physiology: Lung Cellular & Molecular Physiology
#732
of 1,369 outputs
Outputs of similar age
#119,592
of 246,454 outputs
Outputs of similar age from American Journal of Physiology: Lung Cellular & Molecular Physiology
#12
of 65 outputs
Altmetric has tracked 12,497,962 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,369 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,454 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.