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Effects of nutritional supplementation with l-arginine on repair of injuries due to muscle strain: experimental study on rats

Overview of attention for article published in Revista Brasileira de Ortopedia (English Edition), July 2015
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Title
Effects of nutritional supplementation with l-arginine on repair of injuries due to muscle strain: experimental study on rats
Published in
Revista Brasileira de Ortopedia (English Edition), July 2015
DOI 10.1016/j.rboe.2015.07.004
Pubmed ID
Authors

Lauren Izabel Medeiros Couto, William Luiz Wuicik, Ivan Kuhn, Juan Rodolfo Vilela Capriotti, João Carlos Repka

Abstract

To evaluate the influence of oral supplementation with arginine on regeneration of injuries due to straining of the anterior tibial muscle of rats. Twenty-four Wistar rats of weight 492.5 ± 50.45 g were used. Injuries were induced through straining the anterior tibial muscles. The rats were separated into three groups of eight rats each. In the untreated group (UTG), after induction of injuries, the rats were observed for 24 h. In the simulation group (SG) and the arginine group (AG) respectively, the rats received isotonic saline solution and arginine solution via direct gavage, over a seven-day period. At the end of the period, blood samples were collected for serum evaluations of creatine kinase (CK), lactic dehydrogenase (LDH), aspartate aminotransferase (AST) and C-reactive protein (CRP). The right and left anterior tibial muscles were resected for histopathological evaluations on the muscle injuries, investigating edema, hemorrhage and disorganization or morphometric alteration of the muscle fibers. The tissue repair was investigated in terms of proliferation of adipose tissue, angiogenesis and collagen fibers. The ANOVA and Student's t methods were used and p ≤ 0.05 was taken to be statistically significant. In the serum evaluations, the AG showed lower CK assay values and higher AST values. In the histopathological evaluation, the UTG presented edema and hemorrhage compatible with injuries due to strain; the SG presented edema and hemorrhage with proliferation of adipose tissue and collagen fibers; and the AG presented not only the findings of the SG but also, especially, intense angiogenesis. Oral supplementation with arginine did not cause any significant metabolic alterations that would contraindicate its use and it induced angiogenesis during the repair of muscles injured due to strain.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 29%
Student > Bachelor 6 29%
Lecturer > Senior Lecturer 1 5%
Student > Ph. D. Student 1 5%
Professor 1 5%
Other 0 0%
Unknown 6 29%
Readers by discipline Count As %
Nursing and Health Professions 5 24%
Medicine and Dentistry 4 19%
Sports and Recreations 2 10%
Agricultural and Biological Sciences 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 2 10%
Unknown 6 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2015.
All research outputs
#23,319,379
of 25,986,827 outputs
Outputs from Revista Brasileira de Ortopedia (English Edition)
#1
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Outputs of similar age
#238,095
of 278,874 outputs
Outputs of similar age from Revista Brasileira de Ortopedia (English Edition)
#1
of 1 outputs
Altmetric has tracked 25,986,827 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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