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Cost-utility analysis of methylphenidate treatment for children and adolescents with ADHD in Brazil

Overview of attention for article published in Revista Brasileira de Psiquiatria, September 2015
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Title
Cost-utility analysis of methylphenidate treatment for children and adolescents with ADHD in Brazil
Published in
Revista Brasileira de Psiquiatria, September 2015
DOI 10.1590/1516-4446-2014-1516
Pubmed ID
Authors

Maia, Carlos R, Stella, Steffan F, Wagner, Flavia, Pianca, Thiago G, Krieger, Fernanda V, Cruz, Luciane N, Polanczyk, Guilherme V, Rohde, Luís A, Polanczyk, Carísi A

Abstract

To perform a cost-utility analysis on the treatment of attention deficit hyperactivity disorder (ADHD) with methylphenidate immediate-release (MPH-IR) in children and adolescents from Brazil. A Markov model was constructed to compare MPH-IR vs. no treatment. A 24-week naturalistic study was conducted to collect transition probabilities and utility data. Effectiveness was expressed as quality-adjusted life-years (QALY), and costs reported in 2014 international dollars (I$). The perspective was the Brazilian Unified Health System as payer, and the time horizon was 6 years. Of 171 patients, 73 provided information at baseline, and 56 at week 24. Considering the MPH-IR monthly cost of I$ 38, the incremental cost-effectiveness ratio (ICER) of treatment was I$ 9,103/QALY for children and I$ 11,883/QALY for adolescents. In two-way sensitivity analysis, considering one Gross National Product per capita (I$ 11,530) as willingness-to-pay, a cost of no-treatment lower than I$ 45/month would render MPH-IR a cost-saving strategy. MPH-IR treatment of children and adolescents is cost-effective for ADHD patients from the Brazilian public health system perspective. Both patients and the healthcare system might benefit from such a strategy. NCT01705613.

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Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 4%
Unknown 74 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 16%
Student > Master 10 13%
Student > Doctoral Student 6 8%
Student > Ph. D. Student 6 8%
Student > Bachelor 5 6%
Other 16 21%
Unknown 22 29%
Readers by discipline Count As %
Medicine and Dentistry 16 21%
Psychology 8 10%
Pharmacology, Toxicology and Pharmaceutical Science 6 8%
Social Sciences 5 6%
Neuroscience 3 4%
Other 8 10%
Unknown 31 40%