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New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients

Overview of attention for article published in Lipids in Health and Disease, July 2018
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2 tweeters

Citations

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58 Mendeley
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Title
New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients
Published in
Lipids in Health and Disease, July 2018
DOI 10.1186/s12944-018-0833-2
Pubmed ID
Authors

Xin Su, Yi Kong, Dao-quan Peng

Abstract

Apolipoprotein A5 (apoA5) has been identified to play an important role in lipid metabolism, specifically in triglyceride (TG) and TG-rich lipoproteins (TRLs) metabolism. Numerous evidence has demonstrated for an association between apoA5 and the increased risk of obesity and metabolic syndrome, but the mechanism remains to be fully elucidated. Recently, several studies verified that apoA5 could significantly reduce plasma TG level by stimulating lipoprotein lipase (LPL) activity, and the intracellular role of apoA5 has also been proved since apoA5 is associated with cytoplasmic lipid droplets (LDs) and affects intrahepatic TG accumulation. Furthermore, since adipocytes provide the largest storage depot for TG and play a crucial role in the development of obesity, we could infer that apoA5 also acts as a novel regulator to modulate TG storage in adipocytes. In this review, we focus on the association of gene and protein of apoA5 with obesity and metabolic syndrome, and provide new insights into the physiological role of apoA5 in humans, giving a potential therapeutic target for obesity and associated disorders.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 19%
Student > Bachelor 8 14%
Student > Ph. D. Student 5 9%
Other 4 7%
Professor 4 7%
Other 7 12%
Unknown 19 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 21%
Pharmacology, Toxicology and Pharmaceutical Science 6 10%
Medicine and Dentistry 5 9%
Agricultural and Biological Sciences 5 9%
Nursing and Health Professions 3 5%
Other 7 12%
Unknown 20 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2018.
All research outputs
#10,964,713
of 13,804,624 outputs
Outputs from Lipids in Health and Disease
#649
of 992 outputs
Outputs of similar age
#202,438
of 272,025 outputs
Outputs of similar age from Lipids in Health and Disease
#1
of 1 outputs
Altmetric has tracked 13,804,624 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 992 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,025 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them