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A Unique Role of GATA1s in Down Syndrome Acute Megakaryocytic Leukemia Biology and Therapy

Overview of attention for article published in PLOS ONE, November 2011
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Title
A Unique Role of GATA1s in Down Syndrome Acute Megakaryocytic Leukemia Biology and Therapy
Published in
PLOS ONE, November 2011
DOI 10.1371/journal.pone.0027486
Pubmed ID
Authors

Ana C. Xavier, Holly Edwards, Alan A. Dombkowski, Tugce B. Balci, Jason N. Berman, Graham Dellaire, Chengzhi Xie, Steven A. Buck, Larry H. Matherly, Yubin Ge, Jeffrey W. Taub

Abstract

Acute megakaryocytic leukemia (AMkL) in Down syndrome (DS) children is uniformly associated with somatic GATA1 mutations, which result in the synthesis of a shorter protein (GATA1s) with altered transactivation activity compared to the wild-type GATA1. It is not fully established whether leukemogenesis and therapeutic responses in DS AMkL patients are due to loss of the wild-type GATA1 or due to a unique function of GATA1s.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 2 6%
United States 1 3%
Brazil 1 3%
Unknown 31 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 17%
Student > Bachelor 5 14%
Student > Ph. D. Student 5 14%
Student > Master 4 11%
Student > Postgraduate 2 6%
Other 4 11%
Unknown 9 26%
Readers by discipline Count As %
Medicine and Dentistry 10 29%
Biochemistry, Genetics and Molecular Biology 6 17%
Agricultural and Biological Sciences 6 17%
Philosophy 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 2 6%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2011.
All research outputs
#15,238,442
of 22,656,971 outputs
Outputs from PLOS ONE
#129,742
of 193,432 outputs
Outputs of similar age
#84,547
of 125,240 outputs
Outputs of similar age from PLOS ONE
#1,644
of 2,611 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,432 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 125,240 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2,611 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.