Title |
Capsiate treatment in liver surgeries may compromise its recovery1
|
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Published in |
Acta Cirúrgica Brasileira, May 2018
|
DOI | 10.1590/s0102-865020180050000006 |
Pubmed ID | |
Authors |
Pedro Paulo Barros, Gisele Mara Silva Gonçalves, Gustavo Henrique da Silva, Maria Clara Villaça Dias Bastos, Loren Nogaroto Ramos, Marilia Marinello Fernandes |
Abstract |
To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats. The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH. Capsiate treatment interfered with hepatic parameters, reducing the number of mitoses and apoptosis and increasing blood ALT and alkaline phosphatase concentrations. Capsiate treatment preceding hepatic surgery may compromise the initial period of postoperative recovery. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Country | Count | As % |
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Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 43% |
Researcher | 2 | 29% |
Other | 1 | 14% |
Unknown | 1 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 29% |
Unspecified | 1 | 14% |
Nursing and Health Professions | 1 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 14% |
Unknown | 2 | 29% |