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EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling

Overview of attention for article published in Molecular Cell, October 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
6 news outlets
twitter
25 tweeters

Citations

dimensions_citation
70 Dimensions

Readers on

mendeley
157 Mendeley
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Title
EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling
Published in
Molecular Cell, October 2015
DOI 10.1016/j.molcel.2015.09.002
Pubmed ID
Authors

Feng Liu, Gary C. Hon, Genaro R. Villa, Kristen M. Turner, Shiro Ikegami, Huijun Yang, Zhen Ye, Bin Li, Samantha Kuan, Ah Young Lee, Ciro Zanca, Bowen Wei, Greg Lucey, David Jenkins, Wei Zhang, Cathy L. Barr, Frank B. Furnari, Timothy F. Cloughesy, William H. Yong, Timothy C. Gahman, Andrew K. Shiau, Webster K. Cavenee, Bing Ren, Paul S. Mischel

Abstract

Epidermal growth factor receptor (EGFR) gene amplification and mutations are the most common oncogenic events in glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth are not well understood. Here, through integrated epigenome and transcriptome analyses of cell lines, genotyped clinical samples, and TCGA data, we show that EGFR mutations remodel the activated enhancer landscape of GBM, promoting tumorigenesis through a SOX9 and FOXG1-dependent transcriptional regulatory network in vitro and in vivo. The most common EGFR mutation, EGFRvIII, sensitizes GBM cells to the BET-bromodomain inhibitor JQ1 in a SOX9, FOXG1-dependent manner. These results identify the role of transcriptional/epigenetic remodeling in EGFR-dependent pathogenesis and suggest a mechanistic basis for epigenetic therapy.

Twitter Demographics

The data shown below were collected from the profiles of 25 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
Italy 1 <1%
France 1 <1%
Germany 1 <1%
Hungary 1 <1%
Canada 1 <1%
Unknown 150 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 46 29%
Researcher 36 23%
Student > Bachelor 16 10%
Student > Master 15 10%
Unspecified 9 6%
Other 35 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 55 35%
Biochemistry, Genetics and Molecular Biology 42 27%
Medicine and Dentistry 26 17%
Unspecified 12 8%
Neuroscience 6 4%
Other 16 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 55. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2016.
All research outputs
#259,982
of 12,304,689 outputs
Outputs from Molecular Cell
#205
of 5,184 outputs
Outputs of similar age
#8,885
of 255,867 outputs
Outputs of similar age from Molecular Cell
#11
of 83 outputs
Altmetric has tracked 12,304,689 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,184 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,867 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.