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Conservation of Carbohydrate Binding Interfaces — Evidence of Human HBGA Selection in Norovirus Evolution

Overview of attention for article published in PLOS ONE, April 2009
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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2 X users
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1 patent

Citations

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105 Dimensions

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Title
Conservation of Carbohydrate Binding Interfaces — Evidence of Human HBGA Selection in Norovirus Evolution
Published in
PLOS ONE, April 2009
DOI 10.1371/journal.pone.0005058
Pubmed ID
Authors

Ming Tan, Ming Xia, Yutao Chen, Weiming Bu, Rashmi S. Hegde, Jarek Meller, Xuemei Li, Xi Jiang

Abstract

Human noroviruses are the major viral pathogens of epidemic acute gastroenteritis. These genetically diverse viruses comprise two major genogroups (GI and GII) and approximately 30 genotypes. Noroviruses recognize human histo-blood group antigens (HBGAs) in a diverse, strain-specific manner. Recently the crystal structures of the HBGA-binding interfaces of the GI Norwalk virus and the GII VA387 have been determined, which allows us to examine the genetic and structural relationships of the HBGA-binding interfaces of noroviruses with variable HBGA-binding patterns. Our hypothesis is that, if HBGAs are the viral receptors necessary for norovirus infection and spread, their binding interfaces should be under a selection pressure in the evolution of noroviruses.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
Brazil 1 1%
United Kingdom 1 1%
Ukraine 1 1%
Peru 1 1%
Afghanistan 1 1%
Japan 1 1%
United States 1 1%
Poland 1 1%
Other 0 0%
Unknown 76 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 21%
Researcher 18 21%
Student > Master 11 13%
Student > Bachelor 10 12%
Professor 6 7%
Other 12 14%
Unknown 11 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 37 43%
Biochemistry, Genetics and Molecular Biology 12 14%
Medicine and Dentistry 7 8%
Immunology and Microbiology 4 5%
Environmental Science 3 3%
Other 9 10%
Unknown 14 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#6,620,154
of 25,002,811 outputs
Outputs from PLOS ONE
#91,015
of 216,890 outputs
Outputs of similar age
#31,269
of 103,346 outputs
Outputs of similar age from PLOS ONE
#241
of 500 outputs
Altmetric has tracked 25,002,811 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 216,890 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 500 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.