Title |
High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer
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Published in |
Tumor Biology, October 2015
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DOI | 10.1007/s13277-015-4141-4 |
Pubmed ID | |
Authors |
Baoying Yuan, Changshun Wu, Xingwen Wang, Dan Wang, Huiling Liu, Ling Guo, Xiang-An Li, Junqing Han, Hong Feng |
Abstract |
Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan-Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 21% |
Student > Master | 6 | 18% |
Student > Ph. D. Student | 3 | 9% |
Student > Bachelor | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 5 | 15% |
Unknown | 8 | 24% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 12% |
Agricultural and Biological Sciences | 4 | 12% |
Medicine and Dentistry | 4 | 12% |
Immunology and Microbiology | 2 | 6% |
Other | 1 | 3% |
Unknown | 12 | 36% |