Title |
The role of melatonin, a multitasking molecule, in retarding the processes of ageing
|
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Published in |
Ageing Research Reviews, August 2018
|
DOI | 10.1016/j.arr.2018.07.010 |
Pubmed ID | |
Authors |
Maryam Majidinia, Russel J Reiter, Seyed Kazem Shakouri, Bahman Yousefi |
Abstract |
Biological ageing is generally accompanied by a gradual loss of cellular functions and physiological integrity of organ systems, the consequential enhancement of vulnerability, senescence and finally death. Mechanisms which underlie ageing are primarily attributed to an array of diverse but related factors including free radical-induced damage, dysfunction of mitochondria, disruption of circadian rhythms, inflammaging, genomic instability, telomere attrition, loss of proteostasis, deregulated sensing of nutrients, epigenetic alterations, altered intercellular communication, and decreased capacity for tissue repair. Melatonin, a prime regulator of human chronobiological and endocrine physiology, is highly reputed as an antioxidant, immunomodulatory, antiproliferative, oncostatic, and endocrine-modulatory molecule. Interestingly, several recent reports supprot melatonin as an anti-ageing agent whose multifaceted functions may lessen the consequences of ageing. This review depicts four categories of melatonin's protective effects on ageing-induced molecular and structural alterations. We also summarize recent findings related to the function of melatonin during ageing in various tissues and organs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 12 | 24% |
Mexico | 3 | 6% |
United States | 3 | 6% |
Ecuador | 2 | 4% |
France | 2 | 4% |
Argentina | 2 | 4% |
Norway | 1 | 2% |
Chile | 1 | 2% |
Italy | 1 | 2% |
Other | 0 | 0% |
Unknown | 22 | 45% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 42 | 86% |
Practitioners (doctors, other healthcare professionals) | 5 | 10% |
Scientists | 2 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 107 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 12 | 11% |
Researcher | 11 | 10% |
Professor | 10 | 9% |
Student > Ph. D. Student | 9 | 8% |
Student > Master | 8 | 7% |
Other | 23 | 21% |
Unknown | 34 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 15% |
Biochemistry, Genetics and Molecular Biology | 13 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
Neuroscience | 4 | 4% |
Chemistry | 4 | 4% |
Other | 17 | 16% |
Unknown | 46 | 43% |