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Adverse events associated with single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews

Overview of attention for article published in Cochrane database of systematic reviews, October 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

news
1 news outlet
blogs
2 blogs
twitter
37 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
32 Dimensions

Readers on

mendeley
5 Mendeley
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Title
Adverse events associated with single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews
Published in
Cochrane database of systematic reviews, October 2015
DOI 10.1002/14651858.cd011407.pub2
Pubmed ID
Authors

R Andrew Moore, Sheena Derry, Dominic Aldington, Philip J Wiffen

Abstract

This is an update of a Cochrane overview published in Issue 9, 2011; that overview considered both efficacy and adverse events. This overview considers adverse events, with efficacy dealt with in a separate overview.Thirty-nine Cochrane reviews of randomised trials have examined the adverse events associated with individual drug interventions in acute postoperative pain. This overview brings together the results of those individual reviews. To provide an overview of adverse event rates associated with single-dose oral analgesics, compared with placebo, for acute postoperative pain in adults. We identified systematic reviews in The Cochrane Database of Systematic Reviews on The Cochrane Library through a simple search strategy. All reviews were overseen by a single review group. We extracted information related to participants experiencing any adverse event, and reports of serious adverse events, and deaths from the individual reviews. Information was available from 39 Cochrane reviews for 41 different analgesics or analgesic combinations (51 drug/dose/formulations) tested in single oral doses in participants with moderate or severe postoperative pain. This involved around 350 unique studies involving about 35,000 participants. Most studies involved younger participants with pain following removal of molar teeth.For most nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol, and combinations not containing opioids, there were few examples where participants experienced significantly more or fewer adverse events than with placebo. For aspirin 1000 mg and diflunisal 1000 mg, opioids, or fixed-dose combination drugs containing opioids, participants typically experienced significantly more adverse events than with placebo. Studies of combinations of ibuprofen and paracetamol reported significantly fewer adverse events.Serious adverse events were rare, occurring a rate of about 1 in 3200 participants.Most reviews did not report specific adverse events. Despite ongoing problems with the measurement, recording, and reporting of adverse events in clinical trials and in systematic reviews, the large amount of information available for single oral doses of analgesics provides evidence that adverse events rates are generally similar with active drug and placebo in these circumstances, except at higher doses of some drugs, and in combinations including opioids.

Twitter Demographics

The data shown below were collected from the profiles of 37 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 20%
Unknown 4 80%

Demographic breakdown

Readers by professional status Count As %
Lecturer > Senior Lecturer 1 20%
Student > Master 1 20%
Student > Ph. D. Student 1 20%
Researcher 1 20%
Librarian 1 20%
Other 0 0%
Readers by discipline Count As %
Social Sciences 2 40%
Nursing and Health Professions 1 20%
Earth and Planetary Sciences 1 20%
Unspecified 1 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2017.
All research outputs
#420,222
of 13,528,039 outputs
Outputs from Cochrane database of systematic reviews
#1,241
of 10,636 outputs
Outputs of similar age
#11,622
of 251,765 outputs
Outputs of similar age from Cochrane database of systematic reviews
#48
of 266 outputs
Altmetric has tracked 13,528,039 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,636 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,765 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 266 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.