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Evaluation of health benefits and harms of the breast cancer screening programme in the Basque Country using discrete event simulation

Overview of attention for article published in BMC Cancer, October 2015
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Title
Evaluation of health benefits and harms of the breast cancer screening programme in the Basque Country using discrete event simulation
Published in
BMC Cancer, October 2015
DOI 10.1186/s12885-015-1700-4
Pubmed ID
Authors

Arantzazu Arrospide, Montserrat Rue, Nicolien T. van Ravesteyn, Merce Comas, Nerea Larrañaga, Garbiñe Sarriugarte, Javier Mar

Abstract

Since the breast cancer screening programme in the Basque Country (BCSPBC) was started in 1996, more than 400,000 women aged 50 to 69 years have been invited to participate. Based on epidemiological observations and simulation techniques it is possible to extend observed short term data into anticipated long term results. The aim of this study was to assess the effectiveness of the programme through 2011 by quantifying the outcomes in breast cancer mortality, life-years gained, false positive results, and overdiagnosis. A discrete event simulation model was constructed to reproduce the natural history of breast cancer (disease-free, pre-clinical, symptomatic, and disease-specific death) and the actual observed characteristics of the screening programme during the evaluated period in the Basque women population. Goodness-of-fit statistics were applied for model validation. The screening effects were measured as differences in benefits and harms between the screened and unscreened populations. Breast cancer mortality reduction and life-years gained were considered as screening benefits, whereas, overdiagnosis and false positive results were assessed as harms. Results for a single cohort were also obtained. The screening programme yielded a 16 % reduction in breast cancer mortality and a 10 % increase in the incidence of breast cancer through 2011. Almost 2 % of all the women in the programme had a false positive result during the evaluation period. When a single cohort was analysed, the number of deaths decreased by 13 %, and 4 % of screen-detected cancers were overdiagnosed. Each woman with BC detected by the screening programme gained 2.5 life years due to early detection corrected by lead time. Fifteen years after the screening programme started, this study supports an important decrease in breast cancer mortality due to the screening programme, with reasonable risk of overdiagnosis and false positive results, and sustains the continuation of the breast cancer screening programme in the Basque population.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 78 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 27 34%
Researcher 11 14%
Student > Ph. D. Student 11 14%
Student > Bachelor 6 8%
Other 4 5%
Other 10 13%
Unknown 10 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 25%
Medicine and Dentistry 20 25%
Environmental Science 5 6%
Biochemistry, Genetics and Molecular Biology 3 4%
Social Sciences 3 4%
Other 14 18%
Unknown 14 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2015.
All research outputs
#15,348,897
of 22,830,751 outputs
Outputs from BMC Cancer
#4,112
of 8,305 outputs
Outputs of similar age
#163,388
of 279,097 outputs
Outputs of similar age from BMC Cancer
#106
of 239 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,305 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,097 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 239 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.