You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Co-Delivery of Ciprofloxacin and Colistin in Liposomal Formulations with Enhanced In Vitro Antimicrobial Activities against Multidrug Resistant Pseudomonas aeruginosa
|
|---|---|
| Published in |
Pharmaceutical Research, August 2018
|
| DOI | 10.1007/s11095-018-2464-8 |
| Pubmed ID | |
| Authors |
Shaoning Wang, Shihui Yu, Yuwei Lin, Peizhi Zou, Guihong Chai, Heidi H. Yu, Hasini Wickremasinghe, Nivedita Shetty, Junhong Ling, Jian Li, Qi (Tony) Zhou |
| Abstract |
This study aims to develop liposomal formulations containing synergistic antibiotics of colistin and ciprofloxacin for the treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa. Colistin (Col) and ciprofloxacin (Cip) were co-encapsulated in anionic liposomes by ammonium sulfate gradient. Particle size, encapsulation efficiency, in vitro drug release and in vitro antibiotic activities were evaluated. The optimized liposomal formulation has uniform sizes of approximately 100 nm, with encapsulation efficiency of 67.0% (for colistin) and 85.2% (for ciprofloxacin). Incorporation of anionic lipid (DMPG) markedly increased encapsulation efficiency of colistin (from 5.4 to 67.0%); however, the encapsulation efficiency of ciprofloxacin was independent of DMPG ratio. Incorporation of colistin significantly accelerated the release of ciprofloxacin from the DMPG anionic liposomes. In vitro release of ciprofloxacin and colistin in the bovine serum for 2 h were above 70 and 50%. The cytotoxicity study using A549 cells showed the liposomal formulation is as non-toxic as the drug solutions. Liposomal formulations of combinations had enhanced in vitro antimicrobial activities against multidrug resistant P. aeruginosa than the monotherapies. Liposomal formulations of two synergistic antibiotics was promising against multidrug resistant P. aeruginosa infections. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 17% |
| Venezuela, Bolivarian Republic of | 1 | 17% |
| United Kingdom | 1 | 17% |
| South Africa | 1 | 17% |
| Nepal | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 80 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 21% |
| Student > Bachelor | 9 | 11% |
| Researcher | 6 | 8% |
| Student > Master | 6 | 8% |
| Professor > Associate Professor | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 28 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 18% |
| Chemistry | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Medicine and Dentistry | 6 | 8% |
| Agricultural and Biological Sciences | 4 | 5% |
| Other | 7 | 9% |
| Unknown | 34 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2019.
All research outputs
#7,415,511
of 23,337,345 outputs
Outputs from Pharmaceutical Research
#1,012
of 2,888 outputs
Outputs of similar age
#126,329
of 331,977 outputs
Outputs of similar age from Pharmaceutical Research
#7
of 22 outputs
Altmetric has tracked 23,337,345 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,888 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,977 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.