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Co-Delivery of Ciprofloxacin and Colistin in Liposomal Formulations with Enhanced In Vitro Antimicrobial Activities against Multidrug Resistant Pseudomonas aeruginosa

Overview of attention for article published in Pharmaceutical Research, August 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

twitter
6 tweeters

Citations

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17 Dimensions

Readers on

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40 Mendeley
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Title
Co-Delivery of Ciprofloxacin and Colistin in Liposomal Formulations with Enhanced In Vitro Antimicrobial Activities against Multidrug Resistant Pseudomonas aeruginosa
Published in
Pharmaceutical Research, August 2018
DOI 10.1007/s11095-018-2464-8
Pubmed ID
Authors

Shaoning Wang, Shihui Yu, Yuwei Lin, Peizhi Zou, Guihong Chai, Heidi H. Yu, Hasini Wickremasinghe, Nivedita Shetty, Junhong Ling, Jian Li, Qi Zhou

Abstract

This study aims to develop liposomal formulations containing synergistic antibiotics of colistin and ciprofloxacin for the treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa. Colistin (Col) and ciprofloxacin (Cip) were co-encapsulated in anionic liposomes by ammonium sulfate gradient. Particle size, encapsulation efficiency, in vitro drug release and in vitro antibiotic activities were evaluated. The optimized liposomal formulation has uniform sizes of approximately 100 nm, with encapsulation efficiency of 67.0% (for colistin) and 85.2% (for ciprofloxacin). Incorporation of anionic lipid (DMPG) markedly increased encapsulation efficiency of colistin (from 5.4 to 67.0%); however, the encapsulation efficiency of ciprofloxacin was independent of DMPG ratio. Incorporation of colistin significantly accelerated the release of ciprofloxacin from the DMPG anionic liposomes. In vitro release of ciprofloxacin and colistin in the bovine serum for 2 h were above 70 and 50%. The cytotoxicity study using A549 cells showed the liposomal formulation is as non-toxic as the drug solutions. Liposomal formulations of combinations had enhanced in vitro antimicrobial activities against multidrug resistant P. aeruginosa than the monotherapies. Liposomal formulations of two synergistic antibiotics was promising against multidrug resistant P. aeruginosa infections.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 28%
Student > Bachelor 6 15%
Researcher 5 13%
Student > Master 3 8%
Professor > Associate Professor 3 8%
Other 5 13%
Unknown 7 18%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 8 20%
Chemistry 5 13%
Medicine and Dentistry 5 13%
Biochemistry, Genetics and Molecular Biology 5 13%
Engineering 2 5%
Other 5 13%
Unknown 10 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2019.
All research outputs
#5,180,008
of 16,299,115 outputs
Outputs from Pharmaceutical Research
#745
of 2,332 outputs
Outputs of similar age
#109,103
of 280,378 outputs
Outputs of similar age from Pharmaceutical Research
#7
of 31 outputs
Altmetric has tracked 16,299,115 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,332 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,378 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.