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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Proliferative heterogeneity of murine epithelial cells in the adult mammary gland
|
|---|---|
| Published in |
Communications Biology, August 2018
|
| DOI | 10.1038/s42003-018-0114-7 |
| Pubmed ID | |
| Authors |
Mona Shehata, Paul D. Waterhouse, Alison E. Casey, Hui Fang, Lee Hazelwood, Rama Khokha |
| Abstract |
Breast cancer is the most common cancer in females. The number of years menstruating and length of an individual menstrual cycle have been implicated in increased breast cancer risk. At present, the proliferative changes within an individual reproductive cycle or variations in the estrous cycle in the normal mammary gland are poorly understood. Here we use Fucci2 reporter mice to demonstrate actively proliferating mammary epithelial cells have shorter G1 lengths, whereas more differentiated/non-proliferating cells have extended G1 lengths. We find that cells enter into the cell cycle mainly during diestrus, yet the expansion is erratic and does not take place every reproductive cycle. Single cell expression analyses feature expected proliferation markers (Birc5, Top2a), while HR+ luminal cells exhibit fluctuations of key differentiation genes (ER, Gata3) during the cell cycle. We highlight the proliferative heterogeneity occurring within the normal mammary gland during a single-estrous cycle, indicating that the mammary gland undergoes continual dynamic proliferative changes. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 42% |
| United States | 2 | 17% |
| Australia | 1 | 8% |
| Unknown | 4 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 42% |
| Members of the public | 4 | 33% |
| Science communicators (journalists, bloggers, editors) | 3 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 24% |
| Student > Bachelor | 6 | 13% |
| Researcher | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Student > Master | 4 | 9% |
| Other | 4 | 9% |
| Unknown | 12 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 43% |
| Agricultural and Biological Sciences | 7 | 15% |
| Chemical Engineering | 1 | 2% |
| Mathematics | 1 | 2% |
| Nursing and Health Professions | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 13 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2018.
All research outputs
#4,598,513
of 23,314,015 outputs
Outputs from Communications Biology
#2,199
of 4,347 outputs
Outputs of similar age
#87,462
of 331,340 outputs
Outputs of similar age from Communications Biology
#41
of 66 outputs
Altmetric has tracked 23,314,015 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,347 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.2. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,340 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.