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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pericytes are progenitors for coronary artery smooth muscle
|
|---|---|
| Published in |
eLife, October 2015
|
| DOI | 10.7554/elife.10036 |
| Pubmed ID | |
| Authors |
Katharina S Volz, Andrew H Jacobs, Heidi I Chen, Aruna Poduri, Andrew S McKay, Daniel P Riordan, Natalie Kofler, Jan Kitajewski, Irving Weissman, Kristy Red-Horse |
| Abstract |
Epicardial cells on the heart's surface give rise to coronary artery smooth muscle cells (caSMCs) located deep in the myocardium. However, the differentiation steps between epicardial cells and caSMCs are unknown as are the final maturation signals at coronary arteries. Here, we use clonal analysis and lineage tracing to show that caSMCs derive from pericytes, mural cells associated with microvessels, and that these cells are present in adults. During development following the onset of blood flow, pericytes at arterial remodeling sites upregulate Notch3 while endothelial cells express Jagged-1. Deletion of Notch3 disrupts caSMC differentiation. Our data support a model wherein epicardial-derived pericytes populate the entire coronary microvasculature, but differentiate into caSMCs at arterial remodeling zones in response to Notch signaling. Our data is the first demonstration that pericytes are progenitors for smooth muscle, and their presence in adult hearts reveal a new potential cell type for targeting during cardiovascular disease. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 13% |
| United Kingdom | 1 | 13% |
| Germany | 1 | 13% |
| Unknown | 5 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 2 | 25% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Sweden | 1 | <1% |
| Unknown | 152 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 30% |
| Researcher | 23 | 15% |
| Student > Master | 17 | 11% |
| Student > Bachelor | 16 | 10% |
| Student > Doctoral Student | 8 | 5% |
| Other | 16 | 10% |
| Unknown | 29 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 46 | 30% |
| Agricultural and Biological Sciences | 37 | 24% |
| Medicine and Dentistry | 19 | 12% |
| Engineering | 5 | 3% |
| Neuroscience | 5 | 3% |
| Other | 12 | 8% |
| Unknown | 31 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 179. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2020.
All research outputs
#185,707
of 22,830,751 outputs
Outputs from eLife
#452
of 13,834 outputs
Outputs of similar age
#2,786
of 283,771 outputs
Outputs of similar age from eLife
#8
of 258 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,834 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,771 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 258 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.