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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Common Genetic Variants Link the Abnormalities in the Gut-Brain Axis in Prematurity and Autism
|
|---|---|
| Published in |
The Cerebellum, August 2018
|
| DOI | 10.1007/s12311-018-0970-1 |
| Pubmed ID | |
| Authors |
Elżbieta M. Sajdel-Sulkowska, Monika Makowska-Zubrycka, Katarzyna Czarzasta, Kaja Kasarello, Vishal Aggarwal, Michał Bialy, Ewa Szczepanska-Sadowska, Agnieszka Cudnoch-Jedrzejewska |
| Abstract |
This review considers a link between prematurity and autism by comparing symptoms, physiological abnormalities, and behavior. It focuses on the bidirectional signaling between the microbiota and the brain, here defined as the microbiota-gut-vagus-heart-brain (MGVHB) axis and its systemic disruption accompanying altered neurodevelopment. Data derived from clinical and animal studies document increased prevalence of gastrointestinal, cardiovascular, cognitive, and behavioral symptoms in both premature and autistic children and suggest an incomplete maturation of the gut-blood barrier resulting in a "leaky gut," dysbiosis, abnormalities in vagal regulation of the heart, altered development of specific brain regions, and behavior. Furthermore, this review posits the hypothesis that common genetic variants link the abnormalities in the MGVHB axis in premature and autistic pathologies. This hypothesis is based on the recently identified common genetic variants: early B cell factor 1 (EBF1), selenocysteine tRNA-specific eukaryotic elongation factor (EEFSEC), and angiotensin II receptor type 2 (AGTR2), in the maternal and infant DNA samples, associated with risk of preterm birth and independently implicated in a risk of autism. We predict that the AGTR2 variants involved in the brain maturation and oxytocin-arginine-vasopressin (OXT-AVP) pathways, related to social behavior, will contribute to our understanding of the link between prematurity and autism paving a way to new therapies. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 40% |
| Sweden | 1 | 10% |
| Venezuela, Bolivarian Republic of | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 70% |
| Scientists | 2 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 143 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 14% |
| Student > Master | 14 | 10% |
| Student > Bachelor | 14 | 10% |
| Student > Ph. D. Student | 8 | 6% |
| Unspecified | 8 | 6% |
| Other | 25 | 17% |
| Unknown | 54 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 13% |
| Neuroscience | 15 | 10% |
| Psychology | 13 | 9% |
| Biochemistry, Genetics and Molecular Biology | 9 | 6% |
| Unspecified | 8 | 6% |
| Other | 22 | 15% |
| Unknown | 58 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2019.
All research outputs
#7,429,108
of 23,975,976 outputs
Outputs from The Cerebellum
#199
of 957 outputs
Outputs of similar age
#123,117
of 334,241 outputs
Outputs of similar age from The Cerebellum
#3
of 11 outputs
Altmetric has tracked 23,975,976 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 957 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,241 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.