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Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

Overview of attention for article published in Nature Reviews Drug Discovery, August 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
1 news outlet
twitter
68 tweeters
patent
1 patent
facebook
6 Facebook pages

Citations

dimensions_citation
277 Dimensions

Readers on

mendeley
506 Mendeley
citeulike
1 CiteULike
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Title
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Published in
Nature Reviews Drug Discovery, August 2018
DOI 10.1038/nrd.2018.109
Pubmed ID
Authors

Barry Boland, Wai Haung Yu, Olga Corti, Bertrand Mollereau, Alexandre Henriques, Erwan Bezard, Greg M. Pastores, David C. Rubinsztein, Ralph A. Nixon, Michael R. Duchen, Giovanna R. Mallucci, Guido Kroemer, Beth Levine, Eeva-Liisa Eskelinen, Fanny Mochel, Michael Spedding, Caroline Louis, Olivier R. Martin, Mark J. Millan

Abstract

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis represent a major socio-economic challenge in view of their high prevalence yet poor treatment. They are often called 'proteinopathies' owing to the presence of misfolded and aggregated proteins that lose their physiological roles and acquire neurotoxic properties. One reason underlying the accumulation and spread of oligomeric forms of neurotoxic proteins is insufficient clearance by the autophagic-lysosomal network. Several other clearance pathways are also compromised in NDAs: chaperone-mediated autophagy, the ubiquitin-proteasome system, extracellular clearance by proteases and extrusion into the circulation via the blood-brain barrier and glymphatic system. This article focuses on emerging mechanisms for promoting the clearance of neurotoxic proteins, a strategy that may curtail the onset and slow the progression of NDAs.

Twitter Demographics

The data shown below were collected from the profiles of 68 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 506 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 506 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 99 20%
Student > Ph. D. Student 73 14%
Student > Bachelor 59 12%
Student > Master 41 8%
Student > Doctoral Student 30 6%
Other 90 18%
Unknown 114 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 93 18%
Neuroscience 87 17%
Agricultural and Biological Sciences 48 9%
Medicine and Dentistry 41 8%
Chemistry 30 6%
Other 67 13%
Unknown 140 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 50. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2022.
All research outputs
#688,167
of 22,143,852 outputs
Outputs from Nature Reviews Drug Discovery
#329
of 3,309 outputs
Outputs of similar age
#15,952
of 302,652 outputs
Outputs of similar age from Nature Reviews Drug Discovery
#8
of 49 outputs
Altmetric has tracked 22,143,852 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,309 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.2. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,652 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.