Title |
Complex trait subtypes identification using transcriptome profiling reveals an interaction between two QTL affecting adiposity in chicken
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Published in |
BMC Genomics, November 2011
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DOI | 10.1186/1471-2164-12-567 |
Pubmed ID | |
Authors |
Yuna Blum, Guillaume Le Mignon, David Causeur, Olivier Filangi, Colette Désert, Olivier Demeure, Pascale Le Roy, Sandrine Lagarrigue |
Abstract |
Integrative genomics approaches that combine genotyping and transcriptome profiling in segregating populations have been developed to dissect complex traits. The most common approach is to identify genes whose eQTL colocalize with QTL of interest, providing new functional hypothesis about the causative mutation. Another approach includes defining subtypes for a complex trait using transcriptome profiles and then performing QTL mapping using some of these subtypes. This approach can refine some QTL and reveal new ones.In this paper we introduce Factor Analysis for Multiple Testing (FAMT) to define subtypes more accurately and reveal interaction between QTL affecting the same trait. The data used concern hepatic transcriptome profiles for 45 half sib male chicken of a sire known to be heterozygous for a QTL affecting abdominal fatness (AF) on chromosome 5 distal region around 168 cM. |
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