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Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study

Overview of attention for article published in Cardiovascular Diabetology, September 2015
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Title
Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study
Published in
Cardiovascular Diabetology, September 2015
DOI 10.1186/s12933-015-0292-2
Pubmed ID
Authors

Martin Heier, Hanna Dis Margeirsdottir, Mario Gaarder, Knut Haakon Stensæth, Cathrine Brunborg, Peter Abusdal Torjesen, Ingebjørg Seljeflot, Kristian Folkvord Hanssen, Knut Dahl-Jørgensen

Abstract

Advanced glycation end products (AGEs) play a role in the development of late complications and atherosclerosis in diabetes by engaging the receptor for advanced glycation end products, RAGE. Receptor binding leads to activation of the vascular endothelium and increased inflammation in the vessel wall. The soluble variants of the receptor, endogenous secretory RAGE (esRAGE) and the cleaved cell-surface part of RAGE, which together comprise soluble RAGE (sRAGE), are suggested to have a protective effect acting as decoys for RAGE. We aimed to test whether high levels of soluble variants of RAGE could be protective against atherosclerosis development. Participants in the prospective atherosclerosis and childhood diabetes study were examined at baseline (aged 8-18) and at follow-up after 5 years. Both sRAGE and esRAGE were measured by immunoassay in 299 patients with type 1 diabetes and 112 healthy controls at baseline and 241 patients and 128 controls at follow-up. The AGEs methylglyoxal-derived hydroimidazolone-1 (MG-H1) and carboxymethyllysine (CML) were measured by immunoassay. The surrogate markers of atherosclerosis assessed were carotid intima-media thickness (cIMT), C-reactive protein (CRP) and Young's modulus, measures of arterial wall thickness, inflammation and arterial stiffness, respectively. Levels of sRAGE and esRAGE correlated strongly both at baseline and at follow-up in both diabetes patients and controls. With increasing age, mean values of both variants declined, independent of gender, diabetes or pubertal stage. In the diabetes group, multiple regression analysis showed a positive association between both variants of soluble RAGE and cIMT. There was no significant relationship with Young's modulus, but a negative association between sRAGE at baseline and CRP at follow-up. The ratios between the AGEs and the variants of soluble RAGE were increased in diabetes patients compared to controls. The results show a possible protective effect of high levels of sRAGE at baseline against inflammation 5 years later, but not on arterial stiffness or wall thickness, in this cohort of adolescents and young adults with T1D.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 22%
Student > Doctoral Student 5 19%
Student > Postgraduate 3 11%
Researcher 3 11%
Student > Bachelor 3 11%
Other 5 19%
Unknown 2 7%
Readers by discipline Count As %
Medicine and Dentistry 12 44%
Biochemistry, Genetics and Molecular Biology 6 22%
Social Sciences 2 7%
Nursing and Health Professions 1 4%
Immunology and Microbiology 1 4%
Other 1 4%
Unknown 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2015.
All research outputs
#5,540,708
of 6,496,325 outputs
Outputs from Cardiovascular Diabetology
#416
of 499 outputs
Outputs of similar age
#165,779
of 208,493 outputs
Outputs of similar age from Cardiovascular Diabetology
#15
of 16 outputs
Altmetric has tracked 6,496,325 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 499 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.