Here’s some randomized data on clarithromycin despite non randomized data demonstrating increased responses rate: https://t.co/ViCEyj81bU - trial halted early due to ⬆️ adverse events in C arm https://t.co/eod0FMPSjR - despite increased response rates, ⬆
As usual, a fascinating tweetorial into the anti-inflammatory effects of macrolides (cf azithromycin vs COVID). But this comment is the most vital - RCTs aren’t excused with quickly developing situations. You just need quicker RCTs. My hospital’s recruiti
@MohanedEgred Studies like this one are part of the reason why RCTs are necessary, even for medications that are seen as safe. "The study was prematurely stopped due to serious adverse events, in particular serious gastrointestinal complications and septi