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Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps

Overview of attention for article published in Brazilian Journal of Otorhinolaryngology, November 2019
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Title
Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps
Published in
Brazilian Journal of Otorhinolaryngology, November 2019
DOI 10.1016/j.bjorl.2018.07.005
Pubmed ID
Authors

Taku Ito, Satoshi Ikeda, Tomoaki Asamori, Keiji Honda, Yoshiyuki Kawashima, Ken Kitamura, Keiko Suzuki, Takeshi Tsutsumi

Abstract

Chronic rhinosinusitis with nasal polyps is a heterogeneous disease and appropriate diagnostic algorithms in individual cases are necessary for effective medical treatment. The purpose of this study was to clarify the relationship between the pendrin expression of nasal polyps and clinical and pathological characteristic features of eosinophilic chronic rhinosinusitis. A total of 68 patients were classified into eosinophilic chronic rhinosinusitis or non-eosinophilic chronic rhinosinusitis groups according to the degree of eosinophilic infiltration into the nasal polyps. Clinical, hematological, and immunohistochemical analyses were performed and statistically compared between both groups. Thirty-eight were classified into eosinophilic chronic rhinosinusitis and 30 into non-eosinophilic chronic rhinosinusitis groups. There were no significant differences in age distribution, sex ratio, prevalence of asthma, or any other complications between the groups. The mean Lund-Mackay score and the number of serum eosinophils was significantly higher in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis groups. The pendrin expression was more frequently detected in the epithelial surface layer of nasal polyps in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis groups. In addition, mucin 5AC was more widely expressed in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis. Increased expression of pendrin and mucin 5AC in the nasal polyps would be associated with development of eosinophilic chronic rhinosinusitis. This finding could allow the development of a novel therapeutic agent targeted specifically to patients with eosinophilic chronic rhinosinusitis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 3 17%
Researcher 3 17%
Student > Ph. D. Student 2 11%
Student > Bachelor 2 11%
Student > Postgraduate 2 11%
Other 1 6%
Unknown 5 28%
Readers by discipline Count As %
Medicine and Dentistry 7 39%
Unspecified 3 17%
Chemistry 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Unknown 6 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2018.
All research outputs
#14,383,844
of 21,423,731 outputs
Outputs from Brazilian Journal of Otorhinolaryngology
#2
of 8 outputs
Outputs of similar age
#186,866
of 297,988 outputs
Outputs of similar age from Brazilian Journal of Otorhinolaryngology
#5
of 9 outputs
Altmetric has tracked 21,423,731 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8 research outputs from this source. They receive a mean Attention Score of 0.7. This one scored the same or higher as 6 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,988 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.