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Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers

Overview of attention for article published in Journal of Controlled Release, July 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

twitter
2 tweeters
patent
4 patents

Citations

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220 Dimensions

Readers on

mendeley
256 Mendeley

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Title
Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers
Published in
Journal of Controlled Release, July 2012
DOI 10.1016/j.jconrel.2011.11.014
Pubmed ID
22123560
Authors

Claudia Scholz, Ernst Wagner

Abstract

Gene therapy offers great opportunities for the treatment of severe diseases including cancer. In recent years the design of synthetic carriers for nucleic acid delivery has become a research field of increasing interest. Studies on the delivery of plasmid DNA (pDNA) have brought up a variety of gene delivery vehicles. The more recently emerged gene silencing strategy by the intracellular delivery of small interfering RNA (siRNA) takes benefit from existing expertise in pDNA transfer. Despite common properties however, delivery of siRNA also faces distinct challenges due to apparent differences in size, stability of the formed nucleic acid complexes, the location and mechanism of action. This review emphasizes the common aspects and main differences between pDNA and siRNA delivery, taking into consideration a wide spectrum of polymer-based, lipidic and peptide carriers. Challenges and opportunities which result from these differences as well as the recent progress made in the optimization of carrier design are presented.

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Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 256 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
Spain 2 <1%
Iran, Islamic Republic of 1 <1%
United Kingdom 1 <1%
Germany 1 <1%
Unknown 246 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 95 37%
Student > Master 37 14%
Researcher 27 11%
Student > Doctoral Student 23 9%
Student > Bachelor 22 9%
Other 28 11%
Unknown 24 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 56 22%
Chemistry 47 18%
Pharmacology, Toxicology and Pharmaceutical Science 25 10%
Medicine and Dentistry 24 9%
Biochemistry, Genetics and Molecular Biology 20 8%
Other 44 17%
Unknown 40 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2019.
All research outputs
#2,921,765
of 15,766,038 outputs
Outputs from Journal of Controlled Release
#895
of 7,190 outputs
Outputs of similar age
#35,100
of 215,867 outputs
Outputs of similar age from Journal of Controlled Release
#9
of 68 outputs
Altmetric has tracked 15,766,038 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,190 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,867 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.

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