For many viruses, certain HLAs seem to be "better" at selecting the "right" peptides to respond to. For example, in Hepatitis C, the allele HLA-B27 is slightly protective, and this might be because it targets a region of the virus that barely mutates http
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Hepatitis C virus (HCV) infections affect more than 170 million people worldwide. Most of these individuals are... https://t.co/RU5r3BBXN7
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"...using experimentally verified and in silico predicted HCV epitopes..." https://t.co/lfxjZe7ilh
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HLA Preferences for Conserved Epitopes: A Potential Mechanism for Hepatitis C Clearance https://t.co/Mf5lQqxvRV