↓ Skip to main content

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies.

Overview of attention for article published in Current Alzheimer Research, January 2015
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#18 of 673)
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
2 news outlets
twitter
3 tweeters

Citations

dimensions_citation
20 Dimensions

Readers on

mendeley
73 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies.
Published in
Current Alzheimer Research, January 2015
DOI 10.2174/156720501209151019104951
Pubmed ID
Authors

Pickhardt, Marcus, Neumann, Thomas, Schwizer, Daniel, Callaway, Kari, Vendruscolo, Michele, Schenk, Dale, George-Hyslop, Peter St, Mandelkow, Eva M, Dobson, Christopher M, McConlogue, Lisa, Mandelkow, Eckhard, Toth, Gergely, St George-Hyslop, Peter, Tóth, Gergely, Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk, Peter George-Hyslop, Eva Mandelkow, Christopher Dobson, Lisa McConlogue, Eckhard Mandelkow, Gergely Toth

Abstract

A potential strategy to alleviate the aggregation of intrinsically disordered proteins (IDPs) is to maintain the native functional state of the protein by small molecule binding. However, the targeting of the native state of IDPs by small molecules has been challenging due to their heterogeneous conformational ensembles. To tackle this challenge, we applied a high-throughput chemical microarray surface plasmon resonance imaging screen to detect the binding between small molecules and monomeric full-length Tau, a protein linked with the onset of a range of Tauopathies. The screen identified a novel set of drug-like fragment and lead-like compounds that bound to Tau. We verified that the majority of these hit compounds reduced the aggregation of different Tau constructs in vitro and in N2a cells. These results demonstrate that Tau is a viable receptor of drug-like small molecules. The drug discovery approach that we present can be applied to other IDPs linked to other misfolding diseases such as Alzheimer's and Parkinson's diseases.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 73 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 25%
Student > Ph. D. Student 15 21%
Other 10 14%
Student > Doctoral Student 8 11%
Student > Master 5 7%
Other 10 14%
Unknown 7 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 22%
Agricultural and Biological Sciences 14 19%
Neuroscience 13 18%
Chemistry 9 12%
Medicine and Dentistry 6 8%
Other 6 8%
Unknown 9 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2016.
All research outputs
#616,934
of 11,426,369 outputs
Outputs from Current Alzheimer Research
#18
of 673 outputs
Outputs of similar age
#21,544
of 249,190 outputs
Outputs of similar age from Current Alzheimer Research
#1
of 44 outputs
Altmetric has tracked 11,426,369 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 673 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,190 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.