Title |
High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death
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Published in |
BMC Neuroscience, October 2015
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DOI | 10.1186/s12868-015-0202-2 |
Pubmed ID | |
Authors |
Dong Ho Kang, Rok Won Heo, Chin-ok Yi, Hwajin Kim, Chang Hwa Choi, Gu Seob Roh |
Abstract |
Obesity has deleterious effects on the brain, and metabolic dysfunction may exacerbate the outcomes of seizures and brain injuries. However, it is unclear whether obesity affects excitotoxicity-induced neuronal cell death. The purpose of this study was to investigate the effects of a high-fat diet (HFD) on neuroinflammation and oxidative stress in the hippocampus of kainic acid (KA)-treated mice. Mice were fed with a HFD or normal diet for 8 weeks and then received a systemic injection of KA. HFD-fed mice showed hypercholesterolemia, insulin resistance, and hepatic steatosis. HFD-fed mice showed greater susceptibility to KA-induced seizures, an increased number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells, neuroinflammation, and oxidative stress. Furthermore, we found that KA treatment increased HFD-induced calpain1, nuclear factor E2-related factor 2, and heme oxygenase-1 expression in the hippocampus. These findings imply that complex mechanisms affected by obesity-induced systemic inflammation, neuroinflammation, ER stress, calcium overload, and oxidative stress may contribute to neuronal death after brain injury. |
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Geographical breakdown
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Demographic breakdown
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Researcher | 9 | 18% |
Student > Ph. D. Student | 7 | 14% |
Student > Bachelor | 4 | 8% |
Student > Postgraduate | 3 | 6% |
Other | 5 | 10% |
Unknown | 10 | 20% |
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Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Other | 9 | 18% |
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