Title |
Unraveling the Links Between the Initiation of Ventilation and Brain Injury in Preterm Infants
|
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Published in |
Frontiers in Pediatrics, November 2015
|
DOI | 10.3389/fped.2015.00097 |
Pubmed ID | |
Authors |
Samantha K. Barton, Mary Tolcos, Suzie L. Miller, Charles C. Roehr, Georg M. Schmölzer, Peter G. Davis, Timothy J. M. Moss, Domenic A. LaRosa, Stuart B. Hooper, Graeme R. Polglase |
Abstract |
The initiation of ventilation in the delivery room is one of the most important but least controlled interventions a preterm infant will face. Tidal volumes (V T) used in the neonatal intensive care unit are carefully measured and adjusted. However, the V Ts that an infant receives during resuscitation are usually unmonitored and highly variable. Inappropriate V Ts delivered to preterm infants during respiratory support substantially increase the risk of injury and inflammation to the lungs and brain. These may cause cerebral blood flow instability and initiate a cerebral inflammatory cascade. The two pathways increase the risk of brain injury and potential life-long adverse neurodevelopmental outcomes. The employment of new technologies, including respiratory function monitors, can improve and guide the optimal delivery of V Ts and reduce confounders, such as leak. Better respiratory support in the delivery room has the potential to improve both respiratory and neurological outcomes in this vulnerable population. |
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United Kingdom | 1 | 33% |
Switzerland | 1 | 33% |
Canada | 1 | 33% |
Demographic breakdown
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
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Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 20% |
Student > Master | 5 | 9% |
Student > Ph. D. Student | 4 | 7% |
Student > Bachelor | 4 | 7% |
Student > Doctoral Student | 3 | 6% |
Other | 10 | 19% |
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Unspecified | 2 | 4% |
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Engineering | 2 | 4% |
Other | 5 | 9% |
Unknown | 17 | 31% |