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Mendeley readers
Attention Score in Context
| Title |
Dantrolene is neuroprotective in Huntington's disease transgenic mouse model
|
|---|---|
| Published in |
Molecular Neurodegeneration, November 2011
|
| DOI | 10.1186/1750-1326-6-81 |
| Pubmed ID | |
| Authors |
Xi Chen, Jun Wu, Svetlana Lvovskaya, Emily Herndon, Charlene Supnet, Ilya Bezprozvanny |
| Abstract |
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons (MSNs). Our group has previously demonstrated that calcium (Ca2+) signaling is abnormal in MSNs from the yeast artificial chromosome transgenic mouse model of HD (YAC128). Moreover, we demonstrated that deranged intracellular Ca2+ signaling sensitizes YAC128 MSNs to glutamate-induced excitotoxicity when compared to wild type (WT) MSNs. In previous studies we also observed abnormal neuronal Ca2+ signaling in neurons from spinocerebellar ataxia 2 (SCA2) and spinocerebellar ataxia 3 (SCA3) mouse models and demonstrated that treatment with dantrolene, a ryanodine receptor antagonist and clinically relevant Ca2+ signaling stabilizer, was neuroprotective in experiments with these mouse models. The aim of the current study was to evaluate potential beneficial effects of dantrolene in experiments with YAC128 HD mouse model. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 33% |
| Scientists | 1 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Germany | 2 | 3% |
| Austria | 2 | 3% |
| Unknown | 63 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 25% |
| Researcher | 9 | 13% |
| Professor > Associate Professor | 6 | 9% |
| Professor | 5 | 7% |
| Student > Bachelor | 5 | 7% |
| Other | 14 | 20% |
| Unknown | 13 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 25% |
| Neuroscience | 11 | 16% |
| Medicine and Dentistry | 10 | 14% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Computer Science | 2 | 3% |
| Other | 9 | 13% |
| Unknown | 13 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2020.
All research outputs
#1,120,363
of 22,659,164 outputs
Outputs from Molecular Neurodegeneration
#58
of 842 outputs
Outputs of similar age
#7,382
of 239,940 outputs
Outputs of similar age from Molecular Neurodegeneration
#1
of 21 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 842 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,940 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.