Title |
Prolonged low-dose methylprednisolone treatment is highly effective in reducing duration of mechanical ventilation and mortality in patients with ARDS
|
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Published in |
Journal of Intensive Care, August 2018
|
DOI | 10.1186/s40560-018-0321-9 |
Pubmed ID | |
Authors |
Gianfranco Umberto Meduri, Reed A. C. Siemieniuk, Rachel A. Ness, Samuel J. Seyler |
Abstract |
An updated meta-analysis incorporating nine randomized trials (n = 816) investigating low-to-moderate dose prolonged glucocorticoid treatment in acute respiratory distress syndrome (ARDS) show moderate-to-high quality evidence that glucocorticoid therapy is safe and reduces (i) time to endotracheal extubation, (ii) duration of hospitalization, and (iii) mortality (number to treat to save one life = 7), and increases the number of days free from (i) mechanical ventilation, (ii) intensive care unit stay, and (iii) hospitalization. Recent guideline suggests administering methylprednisolone in patients with early moderate-to-severe (1 mg/kg/day) and late persistent (2 mg/kg/day) ARDS (conditional recommendation based on moderate quality of evidence). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 7 | 14% |
Spain | 7 | 14% |
Mexico | 3 | 6% |
United States | 2 | 4% |
Colombia | 2 | 4% |
Ecuador | 1 | 2% |
Brazil | 1 | 2% |
Switzerland | 1 | 2% |
India | 1 | 2% |
Other | 3 | 6% |
Unknown | 21 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 40 | 82% |
Scientists | 4 | 8% |
Practitioners (doctors, other healthcare professionals) | 3 | 6% |
Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 151 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 22 | 15% |
Researcher | 18 | 12% |
Other | 15 | 10% |
Student > Bachelor | 15 | 10% |
Student > Ph. D. Student | 12 | 8% |
Other | 29 | 19% |
Unknown | 40 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 82 | 54% |
Nursing and Health Professions | 6 | 4% |
Biochemistry, Genetics and Molecular Biology | 5 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Agricultural and Biological Sciences | 2 | 1% |
Other | 7 | 5% |
Unknown | 44 | 29% |